Most Read Articles
Roshini Claire Anthony, 5 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 6 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
Pearl Toh, 09 Sep 2019
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.
5 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.

LGBT, gender non-conforming population at greater risk for cognitive decline

Roshini Claire Anthony
07 Aug 2019

Individuals who identify as sexual or gender minorities (SGM) appear to be at a higher risk of experiencing subjective cognitive decline (SCD) than individuals who identify as cisgender and heterosexual, according to a study presented at the Alzheimer’s Association International Conference (AAIC 2019).

The study population comprised 44,403 individuals aged 45 years (mean age 63.5 years) from nine states in the US (Georgia, Hawaii, Illinois, Minnesota, Nevada, Ohio, Virginia, West Virginia, and Wisconsin) who had been enrolled in the 2015 Behavioral Risk Factor Surveillance System.

Three percent of the study population (n=1,253) identified as SGM (lesbian, gay, bisexual, transgender [LGBT] or gender nonconforming). They were younger than their cisgender heterosexual counterparts (mean 62.0 vs 63.5 years), more likely to be unmarried (57.8 percent vs 41.9 percent), unemployed (17.0 percent vs 10.5 percent), uninsured (5.3 percent vs 3.8 percent), or have an annual household income of <USD20,000 (22.8 percent vs 15.6 percent), and were more racially and ethnically diverse (19.3 percent vs 16.0 percent).

More than 14 percent of SGM individuals reported SCD, defined as increasingly worse memory loss or confusion over the past 12 months, compared with 10 percent of cisgender heterosexual individuals (p<0.0001). After adjustment, SGM individuals had a 29 percent higher risk of reporting SCD than cisgender heterosexual individuals (adjusted odds ratio, 1.29, 95 percent confidence interval, 1.08–1.55). [AAIC 2019, abstract O4-07-04]

Compared with cisgender heterosexual individuals, SGM individuals with SCD were more likely to give up day-to-day activities (39 percent vs 29 percent; p=0.003) and require help with household activities (44 percent vs 35 percent; p=0.01).

Reporting of SCD was also low among SGM individuals, with less than half discussing their condition with their healthcare provider, said study lead author Assistant Professor Jason Flatt from the University of California, San Francisco, California, US.

“While we do not yet know for certain why SGM individuals had higher SCD, we believe it may be due to higher rates of depression, inability to work, high stress, and a lack of regular access to healthcare,” said Flatt, who called for further research into examining the elevated risk of cognitive impairment and Alzheimer’s disease in the SGM population.

“Given that one in seven adults who identified as SGM reported SCD, it is critical that more opportunities exist for people in these communities to receive regular evaluation for cognitive impairment and Alzheimer’s disease,” said Flatt, highlighting the importance of early detection of these conditions and interventions and support tailored to this community. 

“There is also a need for greater education on Alzheimer’s risk, signs and symptoms, and training of healthcare providers to ensure inclusive and welcoming care for LGBTQ+ populations,” he added.

 

Developing personalized interventions for LGBT adults with dementia

In a separate study, Professor Karen Fredriksen-Goldsen from the University of Washington, Seattle, Washington, US, shone a light on the interventions that have been developed to improve quality of life (QoL), independence, and physical function in older individuals with dementia or their caregivers, either of whom identified as LGBT. [AAIC 2019, abstract O1-05-06]

These interventions involve identifying and changing the behaviours that negatively impact the individuals with dementia and their caregivers. The interventions, which will be delivered by trained coaches, incorporate a personalized exercise programme, and “behavioural and coping strategies” that will be examined in 225 pairs of older LGBT adults with dementia and their caregivers.

This study, the Aging with Pride: Innovations in Dementia Empowerment and Action (IDEA), follows up on the Aging with Pride: National Heath, Aging, and Sexuality/Gender Study conducted in this population in Seattle, Washington, and Los Angeles and San Francisco, California, US, which identified the factors affecting physical function and QoL among 646 older LGBT adults with dementia. Individuals who had previously experienced discrimination or victimization had poorer QoL, while those who socialized with friends and family had improved QoL. Additionally, physical activity was tied to improved physical function.

Older LGBT adults with dementia also had a higher likelihood of living alone, not having children, being unmarried or without a partner, or without a caregiver compared with older non-LGBT individuals with dementia.

“Given their lifetime experiences of victimization, discrimination, and bias, many LGBT older adults forgo seeking needed medical care,” said Fredriksen-Goldsen. “LGBT people living with dementia and their caregivers often have difficulty accessing information and support services, which can be especially challenging when memory loss and dementia enter the equation,” she said.

 

Editor's Recommendations
Most Read Articles
Roshini Claire Anthony, 5 days ago

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Stephen Padilla, 6 days ago
Implementation of the collaborative care in a rheumatoid arthritis (RA) clinic has led to improvements in nonbiologic disease-modifying antirheumatic drugs (nb-DMARDs) optimization, adherence to safety recommendations on nb-DMARD monitoring and detection of adverse drug events in RA patients, according to a Singapore study.
Pearl Toh, 09 Sep 2019
Use of menopausal hormone therapy (MHT) was associated with a significantly increased risk of invasive breast cancer, which became progressively greater with longer duration of use, a meta-analysis of worldwide prospective epidemiological studies has shown.
5 days ago
Blood pressure (BP) in children is influenced by early-life exposure to several chemicals, built environment and meteorological factors, suggests a study.