Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
3 days ago
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
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The dietary intake of gluten does not appear to be a risk factor for psoriasis, psoriatic arthritis or atopic dermatitis in women, reports a new study.

Levetiracetam holds limited efficacy for neonatal seizure control

03 Dec 2019

Not many preterm infants treated with levetiracetam achieve seizure control, with only about a quarter of extreme preterm neonates responding well to the treatment, a recent study has shown.

Researchers reviewed the medical records of 61 neonates born <28 weeks of gestation. Levetiracetam successfully managed seizures in 16 neonates (26 percent), and the remaining 45 (74 percent) who did not respond to initial therapy required multiple antiseizure medications (p<0.0001).

In the subgroup of infants who were small for gestational age, none responded to levetiracetam monotherapy.

There was no significant difference in mean gestational age between responders and nonresponders overall. Likewise, birthweight did not significantly differ between the two groups (range, 428–903 g).

Compared with responders, the nonresponders who required multiple antiseizure medications had a higher incidence of base deficit <12 on first gas (p=0.016). There was no significant between-group difference in presumed seizure aetiology.

No other risk factors for seizures, such as  intraventricular hemorrhage or hypoxic-ischaemic encephalopathy, were predictive of successful vs unsuccessful levetiracetam monotherapy response.

The present data suggest that levetiracetam has limited efficacy for neonatal seizure control, according to the researchers. More studies are needed to further investigate and validate the low therapeutic response to levetiracetam as the first-line agent in extreme premature neonates with seizures.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
3 days ago
There appears to be no association between aortic pulse wave velocity, a measure of vascular stiffness, and migraine, as reported in a recent study.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
4 days ago
The dietary intake of gluten does not appear to be a risk factor for psoriasis, psoriatic arthritis or atopic dermatitis in women, reports a new study.