Most Read Articles
Yesterday
No association exists between physical activity and the risk of urological cancer, according to a population-based prospective study in Japan.
6 days ago
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
2 days ago
Patients with childhood-onset inflammatory bowel disease are more likely to die than the general population, a study suggests.
2 days ago
Reduced caloric intake results in a significant improvement in glucose metabolism and body-fat composition, including liver-fat content, according to a study. Changes in ferritin levels appear to mediate the striking reduction in liver fat.

Letrozole-clomiphene citrate combo improves ovulation rate in infertile women with PCOS

12 Feb 2019

Combination therapy with letrozole and clomiphene citrate (CC) yields a higher ovulation rate in women with infertility and polycystic ovary syndrome (PCOS) compared with letrozole alone, according to the results of an open-label trial.

The trial randomized 70 women aged 18–40 years with a diagnosis of infertility and PCOS, as defined by the Rotterdam criteria, and no other known cause of infertility to receive either 2.5 mg letrozole alone (n=35) or the combination of 2.5 mg letrozole and 50 mg CC daily (n=35) on cycle days 3–7 for one treatment cycle.

With respect to the primary outcome, the combination therapy was associated with a higher rate of ovulation, defined as mid-luteal serum progesterone concentration ≥3 ng/mL, relative to letrozole monotherapy (77 percent vs 43 percent; rate ratio, 1.80; 95 percent CI, 1.18–2.75; p=0.0068).

On the other hand, there were no significant between-group differences in secondary outcomes such as conception, pregnancy and live birth. Researchers noted that a much larger sample size would be needed to detect differences in these outcomes.

None of the women had multiple-gestation pregnancies. Among those who conceived, rates of pregnancy loss were similar in the two treatment groups. Among those who ovulated, endometrial thickness, median number of follicles >15 mm, largest follicle size and serum progesterone level were also comparable.

The findings indicate that the combination of letrozole and CC is superior to letrozole alone for inducing ovulation in the setting of infertility treatment in women with PCOS, researchers said. This suggests that the combination therapy represents an alternate low-risk, low-cost infertility treatment that offers improved ovulation rates.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Yesterday
No association exists between physical activity and the risk of urological cancer, according to a population-based prospective study in Japan.
6 days ago
Olanzapine confers a modest therapeutic effect on weight compared with placebo in adult outpatients with anorexia nervosa, a study has shown. However, it does not appear to offer significant benefit for psychological symptoms.
2 days ago
Patients with childhood-onset inflammatory bowel disease are more likely to die than the general population, a study suggests.
2 days ago
Reduced caloric intake results in a significant improvement in glucose metabolism and body-fat composition, including liver-fat content, according to a study. Changes in ferritin levels appear to mediate the striking reduction in liver fat.