Most Read Articles
6 days ago
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
6 days ago
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Lenabasum for diffuse cutaneous systemic sclerosis aces phase II trial

2 days ago

Treatment with lenabasum is safe and helps improve outcomes in patients with diffuse cutaneous systemic sclerosis (dcSSc), according to the results of a phase II study.

The study randomized adult patients with dcSSc for ≤6 years and on stable standard‐of‐care treatment to receive either lenabasum (n=27) or placebo (n=15). The study drug was given at 5 mg once daily (QD), 20 mg QD or 20 mg twice daily (BID) for 4 weeks, then 20 mg BID for 8 weeks. Researchers conducted safety and efficacy assessments at weeks 4, 8, 12 and 16.

Active treatment led to a more favourable improvement in American College of Rheumatology Combined Response Index in diffuse cutaneous Systemic Sclerosis (CRISS) score, which reached 0.33 vs 0.00 with placebo at week 16 (p=0.07). Lenabasum also produced greater improvements in other efficacy outcomes that assessed overall disease, skin involvement and patient‐reported function.

Gene expression in inflammation and fibrosis pathways decreased more with the study drug vs placebo, with significant improvements in inflammation and fibrosis by histological evaluation of skin biopsies (p≤0.05).

Adverse events (AEs) occurred in 63 percent of patients in the lenabasum group and in 60 percent of the placebo group. Commonly reported AEs were dizziness (22 percent vs 13 percent), fatigue (19 percent vs 7 percent), headache (11 percent vs 7 percent), arthralgia (11 percent vs 7 percent), upper respiratory tract infection (11 percent vs 0 percent), nausea (4 percent vs 13 percent) and decreased forced vital capacity (0 percent vs 13 percent). There were no serious AEs related to active treatment.

Despite a short trial duration and a small number of patients, the findings are encouraging and support the therapeutic potential of lenabasum in dcSSc, the researchers said, adding that further evaluation of the drug is warranted.

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Most Read Articles
6 days ago
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
6 days ago
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.