Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Left ventricular thrombus worsens outcome after acute STEMI

12 Dec 2019

Cases of in-hospital left ventricular (LV) thrombus are rare following acute ST-elevation myocardial infarction (STEMI), a recent study has found. Nevertheless, LV thrombus is associated with worse clinical outcomes.

Accessing the Nationwide Inpatient Sample database, researchers identified 1,035,888 STEMI patients. Outcomes of interest were in-hospital complications, length of hospital stay, total hospital charges and the factors correlated with LV thrombus incidence. Overall, only 0.2 percent (n=1,982; mean age, 61.9±0.7 years; 24.7 percent female) developed LV thrombus.

Patients with LV thrombus were more likely to develop in-hospital ischaemic stroke (adjusted odds ratio [OR], 5.58, 95 percent confidence interval [CI], 3.53–8.82). The same was true for the risk of in-hospital mortality, though only to a marginal extent (adjusted OR, 1.006, 95 percent CI, 0.54–1.87).

Moreover, those with LV thrombus had a significantly longer hospital stay (8.12±0.36 vs 4.52±0.03 days; p<0.001) and sustained greater costs ($119,463±6,516 vs $85,352±1,139; p<0.001) than their counterparts who did not develop the condition.

Among the factors that increased the likelihood of developing LV thrombus were reduced ejection fraction, either because of chronic (adjusted OR, 2.24, 95 percent CI, 1.73–2.90) or acute (adjusted OR, 1.64, 1.15–2.34) heart failure, and the presence of LV aneurysm (adjusted OR, 5.32, 95 percent CI, 2.63–10.75). Thrombocytopoenia and coagulation defects, on the other hand, reduced the risk of LV thrombus (adjusted OR, 0.44, 95 percent CI, 0.23–0.87).

“[O]ur study may provide further help in identifying STEMI patients who are at higher risk of developing in-hospital LV thrombus, and therefore guide cost-effective utilization of diagnostic procedures,” said researchers.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.