Left ventricular mass index tied to masked hypertension in young healthy adults
Early detection of masked hypertension is essential, since young apparently healthy adults already show an increased left ventricular mass index, which indicates higher risk for future cardiovascular disease, according to a recent study.
Of the patients, 16.4 percent had masked hypertension (60.6 percent whites; 67.7 percent men). In multiple-adjusted logistic regression analysis, masked hypertensive patients were shown to have higher chances of presenting with increased left ventricular mass index (odds ratio, 1.67; p=0.031) compared with normotensive individuals.
Multivariable-adjusted linear regression analyses revealed that left ventricular mass index was positively and independently associated with masked hypertension (adjusted R2, 0.193; β, 0.08; 0.01–0.16; p=0.046). However, there was no independent correlation between echocardiographic measures of left ventricular function and masked hypertension.
A previous study found that left ventricular mass highly correlated with body weight, subscapular skinfold thickness, height and systolic blood pressure across race and sex subgroups. Left ventricular mass also remained higher in men than in women and in blacks than in whites after adjusting for anthropometric, blood pressure and other covariates. [Circulation 1995;92:380-387]
The present cross-sectional study included 774 black and white men and women (aged 20–30 years) who had successful ambulatory blood pressure monitoring readings (>70-percent valid readings) and valid echocardiography done.
“Masked hypertension is reportedly common in young adults,” the investigators said. “However, it is unknown if these masked hypertensive individuals already present with organ damage.”