Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

LDL, total cholesterol predict new-onset atrial fibrillation in ASTEMI patients

09 Nov 2019

In patients with acute ST-segment elevation myocardial infarction (ASTEMI), the risk of new-onset atrial fibrillation (NOAF) appears to be linked with plasma levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), a recent China study has found.

Of the 985 ASTEMI patients (mean age, 63.4±12.6 years; 79.9 percent male) enrolled, 81 developed NOAF over 31 months of observation. The resulting incidence rate was 8.2 percent. These patients tended to present with significantly lower LDL-C, TC and triglyceride concentrations.

Multivariable logistic regression analysis found that, when grouped into tertiles of lipid concentrations, participants in the middle (odds ratio [OR], 0.46, 95 percent confidence intervals [CI], 0.22–0.98; p=0.044) and topmost (OR, 0.24, 95 percent CI, 0.1–0.58; p=0.002; p-trend=0.004) categories of TC benefited from significant protection against NOAF.

A similar and significant (p=0.001) trend was observed for LDL-C (middle tertile: OR, 0.23, 95 percent CI, 0.10–0.53; p=0.001; top tertile: OR, 0.38, 95 percent CI, 0.17–0.83; p=0.015).

In contrast, triglyceride levels and concentrations of high-density lipoprotein cholesterol were unrelated to the risk of developing NOAF.

In terms of outcomes, NOAF patients had an all-cause mortality rate of 19.8 percent. Kaplan-Meier analysis found that this was significantly higher than that in the sinus rhythm comparators (6.1 percent; log-rank p<0.001). Cardiogenic shock was likewise greater (17.3 percent vs 6.6 percent; p<0.001) and hospital stay was longer (10.1±5.3 vs 8.3±4.7 days; p=0.002) in the NOAF group.

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.