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20 Jun 2020
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Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
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Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
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Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.

LDL, total cholesterol predict new-onset atrial fibrillation in ASTEMI patients

09 Nov 2019

In patients with acute ST-segment elevation myocardial infarction (ASTEMI), the risk of new-onset atrial fibrillation (NOAF) appears to be linked with plasma levels of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), a recent China study has found.

Of the 985 ASTEMI patients (mean age, 63.4±12.6 years; 79.9 percent male) enrolled, 81 developed NOAF over 31 months of observation. The resulting incidence rate was 8.2 percent. These patients tended to present with significantly lower LDL-C, TC and triglyceride concentrations.

Multivariable logistic regression analysis found that, when grouped into tertiles of lipid concentrations, participants in the middle (odds ratio [OR], 0.46, 95 percent confidence intervals [CI], 0.22–0.98; p=0.044) and topmost (OR, 0.24, 95 percent CI, 0.1–0.58; p=0.002; p-trend=0.004) categories of TC benefited from significant protection against NOAF.

A similar and significant (p=0.001) trend was observed for LDL-C (middle tertile: OR, 0.23, 95 percent CI, 0.10–0.53; p=0.001; top tertile: OR, 0.38, 95 percent CI, 0.17–0.83; p=0.015).

In contrast, triglyceride levels and concentrations of high-density lipoprotein cholesterol were unrelated to the risk of developing NOAF.

In terms of outcomes, NOAF patients had an all-cause mortality rate of 19.8 percent. Kaplan-Meier analysis found that this was significantly higher than that in the sinus rhythm comparators (6.1 percent; log-rank p<0.001). Cardiogenic shock was likewise greater (17.3 percent vs 6.6 percent; p<0.001) and hospital stay was longer (10.1±5.3 vs 8.3±4.7 days; p=0.002) in the NOAF group.

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Pearl Toh, 4 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
3 days ago
Patients with psoriatic arthritis (PsA) often suffer from liver abnormalities, which are associated with higher body mass index (BMI), daily consumption of alcohol, more severe disease, and some therapies, according to a recent study.
Christina Lau, 2 days ago

Pembrolizumab in combination with chemotherapy significantly improves progression-free survival (PFS) vs chemotherapy alone in patients with previously untreated, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC), results of the KEYNOTE-355 study have shown.