Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Tristan Manalac, 4 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.
3 days ago
In a webinar held on 27 March 2021, paediatric endocrinology nurses Karen Blair, Kate Davies, and Siti Zarina Yaakop shared insights and clinical experience based on their frontline roles in caring for patients with central precocious puberty (CPP) and supporting their family members.

Latent TB treatment in dialysis patients safe but requires close monitoring

6 days ago

Many patients receiving maintenance dialysis can complete latent tuberculosis (TB) infection (LTBI) therapy, a recent study reports. However, the risk of high-grade adverse events (AEs) is high and related to frequent medication changes during therapy.

The retrospective cohort study included 365 patients who had undergone at least 90 days of dialysis and initiated LTBI therapy. Of these, 290 (79.5 percent) people were in the recent cohort (2012 onward) and 75 (20.5 percent) were in the historical cohort (before 2012).

Descriptive statistics were used to report outcomes. Two-sample test of proportions using χ2 distribution was applied to test for statistical significance between the recent and historical cohorts.

Majority of the population (n=298, 81.6 percent) successfully completed LTBI therapy. In total, 21.1 percent of patients developed a grade 3 to 4 AE or rash of any grade. Most AEs were related to gastrointestinal events, general malaise, or pruritus that led to changes in their treatment regimen. Two patients (0.5 percent) were hospitalized for AEs related to LTBI therapy.

There were no significant differences observed between the recent and historical cohorts in all outcomes of interest.

Finally, none of grade 5 AEs (deaths) documented were attributed to LTBI therapy.

Maintenance dialysis patients are at an increased risk of active TB, and the present data indicate that LTBI therapy in this population can be safe but requires close monitoring.

The study was limited by the retrospective nature of data and generalizability outside low-TB-burden settings.

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Most Read Articles
Pearl Toh, 3 days ago
Not only does the CGRP* inhibitor galcanezumab show sustained efficacy in migraine patients, long-term treatment does not come with excess cardiovascular (CV) risk, according to studies presented at the AAN 2021 Annual Meeting.
01 Apr 2021
Migraine and headache are common ailments of people living in the modern era. Dr Jon Marshall of The Singapore Headache and Migraine Clinic shares his insights with Pearl Toh on how to manage migraine and headache using non-pharmaceutical strategies, with a focus on the manual medicine approach.
Tristan Manalac, 4 days ago
Visceral fat area is the strongest indicator of mobility disability among obese, community-dwelling, older adults, according to a recent Singapore study.
3 days ago
In a webinar held on 27 March 2021, paediatric endocrinology nurses Karen Blair, Kate Davies, and Siti Zarina Yaakop shared insights and clinical experience based on their frontline roles in caring for patients with central precocious puberty (CPP) and supporting their family members.