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Stephen Padilla, 4 days ago
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Jairia Dela Cruz, 3 days ago
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Laparoscopic appendectomy found safe

03 Dec 2019

Laparoscopic appendectomy (LA) is safe, carrying low rates of complications, readmission and prolonged length of stay (LOS), a recent study has found. Risk factors for these adverse outcomes include complicated appendicitis and intraoperative complications.

The study included 4,618 patients (median age, 33 years; 52.2 percent male) qualified for laparoscopic appendectomy. Majority (69.60 percent; n=3,214) belonged to class I of the American Society of Anaesthesiologists classification. Acute appendicitis symptoms presented within 48 hours of surgery in 31.68 percent of the patients.

A total of 310 patients experienced postoperative morbidity, resulting in a rate of 6.71 percent. In terms of complications, there were reports of surgical site infections, intra-abdominal abscesses and bleeding, pneumonia, urinary tract infection, bowel perforation, pulmonary embolism, and deep vein thrombosis.

Multivariate logistic regression analysis found that the occurrence of intraoperative adverse events (odds ratio [OR], 4.09, 95 percent confidence interval [CI], 1.32–12.65; p=0.014) and complicated appendicitis (OR, 3.63, 95 percent CI, 1.74–7.61; p=0.001) were significant predictors of perioperative serious complications.

In comparison, predictors of prolonged LOS included complicated appendicitis (OR, 2.8, 95 percent CI, 1.53–5.12; p=0.001), postoperative morbidity (OR, 5.01, 95 percent CI, 2.33–10.75; p<0.001), conversion of procedure (OR, 6.48, 95 percent CI, 3.48–12.08; p<0.001) and the need for reinterventions after the primary procedure (OR, 8.79, 95 percent CI, 3.2–24.14; p<0.001).

Hospital readmission were predicted by postoperative complications (OR, 10.33, 95 percent CI, 4.27–25.00), undergoing reinterventions after the procedure (OR, 5.62, 95 percent CI, 2.17–14.54) and LA performed by the resident (OR, 1.96, 1.03–3.70).

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Most Read Articles
Elaine Soliven, 4 days ago

Switching from efavirenz/emtricitabine/tenofovir disoproxil fumarate (EFV/FTC/TDF) to the new bictegravir/ emtricitabine/tenofovir alafenamide (BIC/FTC/TAF) regimen maintained high rates of virological suppression in adults who are living with HIV*, according to a study presented at AIDS 2020.

3 days ago
Among individuals with abdominal obesity, drinking beverages with artificial sweeteners (ASBs) or no sugar (USBs) instead of sugar-sweetened beverages (SSBs) helps lose body weight, a study has found. However, USBs have a more favourable effect on sweet taste preference compared with ASBs.
Stephen Padilla, 4 days ago
Pre-exposure prophylaxis (PrEP) containing either long-acting injectable cabotegravir (CAB) or tenofovir/emtricitabine (TDF/FTC) is safe and effective for transgender women (TGW) and cisgender men who have sex with men (MSM), but CAB results in a much lower HIV incidence compared to TDF/FTC, results of the HIV Prevention Trials Network (HPTN) 083 have shown.
Jairia Dela Cruz, 3 days ago
Monthly prophylaxis with the fixed-dose combination of naphthoquine-azithromycin (NQAZ) is well tolerated and confers significant protection against infection with Plasmodium parasites among individuals residing in malaria-endemic areas in Southeast Asia, as shown in the results of a phase III trial.