Most Read Articles
3 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 2 days ago
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Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Lansoprazole as good as famotidine for preventing recurrent bleeding after ulcer

30 Jul 2019

Recurrent bleeding rates among patients with a history of Helicobacter pylori-negative idiopathic ulcer bleeding are low and do not significantly differ between users of the proton pump inhibitor (PPI) lansoprazole and the histamine 2 receptor antagonist (H2RA) famotidine, according to the results of an industry-independent trial.

The trial randomized 228 patients with a history of idiopathic bleeding ulcers to receive oral lansoprazole 30 mg (n=114; mean age, 67.6 years; 68.4 percent male) or famotidine 40 mg (n=114; mean age, 69.6 years; 55.3 percent male) daily for 24 months.

The primary endpoint of recurrent upper gastrointestinal (GI) bleeding within 24 months occurred in one patient in the lansoprazole arm (duodenal ulcer) and in three patients in the famotidine arm (two gastric ulcers and one duodenal ulcer), with corresponding cumulative incidence rates of 0.88 percent and 2.63 percent (crude hazard ratio, 0.33, 95 percent CI, 0.03–3.16; p=0.336).

None of the patients who experienced bleeding recurrence used aspirin, nonsteroidal anti-inflammatory drugs or other antithrombotic drugs.

The number of patients who discontinued treatment were similar: 27 (23.7 percent) in the lansoprazole arm and 26 (22.8 percent) in the famotidine arm. No cases of upper GI bleeding recurrence were recorded in the group of patients who discontinued medication early.

These findings provide novel data that may be used for future practice guidelines in the management of patients with a history of H. pylori-negative idiopathic bleeding ulcers, the researchers said.

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Most Read Articles
3 days ago
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Tristan Manalac, 2 days ago
Minimally invasive pancreatectomy (MIP) offers a feasible alternative to open pancreatectomy (OP) for the treatment of pancreatic neuroendocrine neoplasms (PNEN), according to a recent Singapore study has found.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.