Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Stephen Padilla, 15 Jun 2020
Consumption of whole almonds as snacks not only reduces low-density lipoprotein cholesterol (LDL-C) but also significantly improves endothelial function in adults with above-average risk of cardiovascular disease (CVD), according to the results of a trial.
Pearl Toh, 2 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.

Lactin-V reduces bacterial vaginosis recurrence

Elaine Soliven
2 days ago

Treatment with Lactobacillus crispatus CTV-05 (Lactin-V) significantly reduces the incidence of bacterial vaginosis recurrence in women who were previously treated with vaginal metronidazole, according to a recent study.

“The use of Lactin-V after treatment with vaginal metronidazole for bacterial vaginosis resulted in a significantly lower incidence of recurrence of bacterial vaginosis at 12 weeks than placebo, and the benefit appeared to persist through week 24,” according to the researchers.

This phase IIb, double-blind, multicentre trial involved 228 women diagnosed with bacterial vaginosis who completed a 5-day course of vaginal 0.75% metronidazole gel within 30 days before the screening visit. Participants were randomized in a 2:1 ratio to receive either Lactin-V (2x109 colony-forming units [CFU] per dose; n=152) or matching placebo (n=76) for 11 weeks. [N Engl J Med 2020;382:1906-1915]

At week 12, the incidence of bacterial vaginosis recurrence was significantly lower in the Lactin-V group compared with the placebo group (30.0 percent vs 45.0 percent; risk ratio [RR], 0.66; p=0.01).

By week 24, the incidence of bacterial vaginosis recurrence was still lower among patients treated with Lactin-V compared with placebo (12.0 percent vs 17.0 percent; RR, 0.73), although this was not significant.

A higher percentage of patients on Lactin-V than placebo had detectable L. crispatus CTV-05 at 12 weeks (79.0–84.0 percent vs 2.0–6.0 percent) and 24 weeks (48.0 percent vs 2.0 percent). The median L. crispatus CTV-05 concentration in the Lactin-V group was 1.7x106–6.2x106 CFU/mL at week 12 and 5.6x106 CFU/mL at week 24.

Abnormal vaginal discharge, abnormal vaginal odour, external genital irritation, and genital itching were the most common solicited local adverse events (AEs) reported in both treatment groups.

The incidence of solicited or unsolicited AEs was comparable between the Lactin-V and placebo groups (87.0 percent vs 79.0 percent [solicited] and 42.0 percent vs 29.0 percent [unsolicited]). Severe grade 3 AEs occurred in four patients in the Lactin-V group and three patients in the placebo group, but none were considered treatment related.

“Lactin-V is a live biotherapeutic product that contains a naturally occurring vaginal strain of L. crispatus … [It] is designed to promote community state type (ie, microbial composition) with a predominance of L. crispatus after treatment with vaginal 0.75% metronidazole gel,” said the researchers.

“These results extend earlier findings seen with Lactin-V and support the general safety of the current formulation and dosing strategy, … although further study should be considered to assess longer-term sustainability of colonization and prevention of bacterial vaginosis,” they added.

 

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Stephen Padilla, 15 Jun 2020
Consumption of whole almonds as snacks not only reduces low-density lipoprotein cholesterol (LDL-C) but also significantly improves endothelial function in adults with above-average risk of cardiovascular disease (CVD), according to the results of a trial.
Pearl Toh, 2 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.