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Lactate dehydrogenase may help identify patients at risk of severe COVID-19

04 Apr 2020

Lactate dehydrogenase (LDH) may be predictive of severe coronavirus disease 2019 (COVID-19), a new study has shown.

Researchers conducted a retrospective and observational analysis of 47 confirmed COVID-19 patients (median age, 64.91 years; 55.31 percent male). LDH was measured through routine laboratory assessments, and disease severity was evaluated using The American Thoracic Society guidelines for community-acquired pneumonia.

Of the participants, 24 had severe disease. This subgroup was more likely to have underlying coronary heart disease and autoimmune diseases than their nonsevere comparators. Clinical severity and chest imaging results were also worse in these patients. LDH (p<0.001), along with other laboratory indices, was likewise significantly elevated in patients with severe disease.

Multivariate logistic regression analysis identified LDH as a significant predictor of severe COVID-19 (odds ratio [OR], 1.02, 95 percent confidence interval [CI], 1.01–1.03; p=0.035). Other univariate risk factors, such as blood cell count, neutrophil counts and serum C-reactive protein, were attenuated upon adjustment for confounders.

Similarly, LDH emerged as an independent predictor of COVID-19 clinical severity and lung damage, and correlated well with markers of inflammation and cardiac and liver injury.

Receiver operating characteristic curve analysis further showed that beyond the threshold value of 283 U/L, serum LDH was a highly accurate predictor of severe COVID-19 (area under the curve, 0.9727), with a sensitivity of 100 percent and a specificity of 86.67 percent.

This study is a preprint and is pending peer review.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Pearl Toh, 26 Nov 2020
Inhaled corticosteroid (ICS) should be the mainstay of long-term asthma management — such is the key message of the latest Singapore ACE* Clinical Guidance (ACG) for asthma, released in October 2020.
4 days ago
Daily intake of cow’s milk formula in early life helps prevent the development of cow’s milk allergy later on without competing with breastfeeding, a recent study has found.