Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 3 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.

Lactate clearance predicts mortality in sepsis patients during initial phase of resuscitation

08 Jun 2019

Arterial lactate concentrations and lactate clearance are predictors of mortality in patients with sepsis during the initial phase of resuscitation, a new study has found.

Researchers collected serum samples from 100 septic shock patients (mean age, 63±11 years; 57 males) at baseline and after 6 hours of resuscitation. Samples were drawn from both arterial and venous lines. Demographic variables, information on acute and chronic health status, and sequential organ failure assessment (SOFA) scores, among others, were also included in the analysis.

The average serum arterial and venous lactate concentrations at baseline were 3.0±0.6 and 3.7±0.8 mg/dL, respectively. In both sets of samples, the serum lactate levels dropped significantly after 6 hours of resuscitation (arterial: mean difference, 0.86, 95 percent CI, 0.74–0.98; venous: mean difference, 0.98, 0.81–1.15).

Baseline arterial and venous lactate concentrations shared a direct, linear and significant correlation (R2, 0.587; p<0.001), which grew even stronger after 6 hours of resuscitation (R2, 0.887; p<0.00). However, venous samples consistently had higher lactate levels than the arterial counterparts.

Receiver operator characteristic curve analysis showed that baseline arterial lactate concentration (area under the curve [AUC], 0.85±0.05) was a stronger predictor of mortality in the ICU than venous levels (AUC, 0.74±0.06; p<0.001). The respective cutoff values were 3.2 and 4.0 mg/dL.

Lactate clearance, defined as the removal of both arterial (AUC, 0.89±0.04) and venous (AUC, 0.85±0.05) lactate after 6 hours of resuscitation, was an even better predictor of ICU mortality than baseline arterial lactate.

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, 2 days ago

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 3 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
14 Sep 2019
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.