Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 3 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

L-Arginine–tadalafil combo effective for diabetics with erectile dysfunction

09 Sep 2019

The combination of L-Arginine and tadalafil improves erectile function among diabetic men with erectile dysfunction, a recent study has found.

Researchers conducted a double-blinded, randomized, controlled clinical trial including 108 diabetic men who received L-Arginine alone (n=27; mean age, 43.19±4.8 years), tadalafil alone (n=27; mean age, 43.04±5.9 years), both medications (n=27; mean age, 45.33±4.3 years) or placebo (n=27; mean age, 43.11±4.6 years). The International Index of Erectile Function 5-item (IIEF-5) questionnaire was used to measure erectile function.

Scores in the IIEF-5 improved after treatment with both L-Arginine (12.22±1.5 to 18.33±1.8) and tadalafil (12.44±1.4 to 20.07±1.4), such that changes were significantly greater than those in the placebo group (p<0.001 for both). The same was true for participants who received both medications (13.67±2.2 to 23.52±1.3; p<0.001).

Between-treatment comparisons showed that the change in IIEF-5 scores was significantly greater in the tadalafil vs L-Arginine group (p<0.001), but that the combination was significantly superior to both tadalafil alone (percent change: 82.88±7.1 percent vs 62.89±3.7 percent; p=0.007) and L-Arginine alone (percent change: 52.21±4.3 percent vs 82.88±7.1 percent; p<0.001).

Similar patterns of change were reported for total testosterone concentrations, which significantly increased in all treated participants, but not in those who received placebo. Tadalafil again elicited significantly greater changes than L-Arginine (p<0.001), while the treatment combination emerged as the most effective intervention (p<0.011).

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 3 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.