L-Arginine–tadalafil combo effective for diabetics with erectile dysfunction
The combination of L-Arginine and tadalafil improves erectile function among diabetic men with erectile dysfunction, a recent study has found.
Researchers conducted a double-blinded, randomized, controlled clinical trial including 108 diabetic men who received L-Arginine alone (n=27; mean age, 43.19±4.8 years), tadalafil alone (n=27; mean age, 43.04±5.9 years), both medications (n=27; mean age, 45.33±4.3 years) or placebo (n=27; mean age, 43.11±4.6 years). The International Index of Erectile Function 5-item (IIEF-5) questionnaire was used to measure erectile function.
Scores in the IIEF-5 improved after treatment with both L-Arginine (12.22±1.5 to 18.33±1.8) and tadalafil (12.44±1.4 to 20.07±1.4), such that changes were significantly greater than those in the placebo group (p<0.001 for both). The same was true for participants who received both medications (13.67±2.2 to 23.52±1.3; p<0.001).
Between-treatment comparisons showed that the change in IIEF-5 scores was significantly greater in the tadalafil vs L-Arginine group (p<0.001), but that the combination was significantly superior to both tadalafil alone (percent change: 82.88±7.1 percent vs 62.89±3.7 percent; p=0.007) and L-Arginine alone (percent change: 52.21±4.3 percent vs 82.88±7.1 percent; p<0.001).
Similar patterns of change were reported for total testosterone concentrations, which significantly increased in all treated participants, but not in those who received placebo. Tadalafil again elicited significantly greater changes than L-Arginine (p<0.001), while the treatment combination emerged as the most effective intervention (p<0.011).