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Roshini Claire Anthony, 11 Sep 2019

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Elvira Manzano, Yesterday

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Kids with Crohn’s disease tolerate an exclusion diet with PEN better than EEN

08 Aug 2019
Among the 20 child or youth suicide cases, 14 persons jumped from height to their death, with the youngest one aged only 11.

For children with mild-to-moderate Crohn’s disease (CD), a CD exclusion diet (CDED) combined with partial enteral nutrition (PEN) is more tolerable than exclusive enteral nutrition (EEN), a recent study has found.

Researchers randomly assigned 74 children with mild-to-moderate CD to undergo diet regimens involving either CDED with 50 percent of calories from formula followed by CDED with 25 percent PEN (group 1; n=40; mean age, 13.8±2.8 years; 65 percent male) or EEN followed by free diet with 25 percent PEN (group 2; n=38; mean age, 14.5±2.6 years; 59 percent male). The overall duration of the trial was 12 weeks, with each phase lasting 6 weeks.

Tolerance to the diet, measured according to withdrawals due to refusal to continue the trial, was significantly better in group 1 (97.5 percent vs 73.7 percent; p=0.002). Children assigned to the CDED+PEN diet were more likely to complete the trial than their EEN counterparts (odds ratio [OR], 13.92, 95 percent CI, 1.68–115.14).

In terms of secondary endpoints, researchers recorded no significant between-group difference in terms of response rate (CDED+PEN vs EEN: 85 percent vs 85.3 percent; p=0.97; OR, 0.97, 0.27–3.53) and corticosteroid-free remission (80 percent vs 73.5 percent; p=0.51; OR, 1.44, 0.49–4.27).

Both dietary interventions also resulted in significant improvements from baseline in inflammatory markers, scores in the paediatric CD activity index and mean weight z-scores. Between-group comparisons did not result in statistically significant figures.

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Most Read Articles
Roshini Claire Anthony, 11 Sep 2019

Beta-blockers could reduce mortality risk in patients with heart failure with reduced ejection fraction (HFrEF) and moderate or moderately-severe renal dysfunction without causing harm, according to the BB-META-HF* trial presented at ESC 2019.

Elvira Manzano, Yesterday

The US Preventive Services Task Force (USPSTF), in an update of its 2013 recommendations, called on clinicians to offer risk-reducing medications to women who are at increased risk for breast cancer but at low risk for adverse effects.

Pearl Toh, 2 days ago
The use of SGLT-2* inhibitors was not associated with a higher risk of severe or nonsevere urinary tract infections (UTIs) in patients with type 2 diabetes (T2D) compared with DPP**-4 inhibitors or GLP-1*** receptor agonists, a population-based cohort study shows.
5 days ago
In type 2 diabetes patients taking sulfonylureas, hypoglycaemia duration is longer at night and is inversely correlated with the level of glycated haemoglobin (HbA1c), a new study reports.