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01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
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Kidney function worsens soon after acute coronary syndrome

07 Dec 2019

Renal function appears to deteriorate immediately after the index acute coronary syndrome (ACS) event and stabilizes not during hospitalization but, on average, 2 weeks after, a recent study has shown. Serial measurement of cystatin C levels may help assess risks of mortality or ACS recurrence.

Using routine laboratory techniques, researchers measured the changes in creatinine and cystatin C levels in 844 ACS patients (median age, 62.5 years; 77.9 percent male) over time. The primary outcome was the effect of the marker trajectories on cardiovascular death or hospitalization for recurrent, nonfatal ACS. A subsample of 185 patients were selected for the analysis of washout patterns of the biomarkers.

A total of 687 samples were retrieved from the washout patients. Analysis of biomarker evolution found that cystatin C levels peaked on the third day after the index ACS episode, while creatinine reached its highest concentration on the sixth day. Estimated glomerular filtration rate (eGFR), on the other hand, reached its nadir on the fourth day.

The markers took different durations to stabilize. For instance, cystatin C concentrations stabilized after 11 days, such that its plateau was reached 13 days after the index event. Creatinine and eGFR each required 10 and 8 days to stabilize. In all three cases, stability was temporary.

Elevated cystatin C levels were significantly predictive of the primary endpoint (adjusted hazard ratio [HR], per standard deviation increase in 2log concentration, 1.63, 95 percent confidence interval [CI], 1.01–2.66; p=0.043). The same was true for its serial measurement >7 days after index ACS (adjusted HR, 1.63, 95 percent CI, 1.01–2.57; p=0.045).

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.