Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.

Kidney function linked to glaucoma in certain East Asian populations

Roshini Claire Anthony
11 Mar 2020

Chronic kidney disease (CKD) may be linked to primary open-angle glaucoma (POAG) in individuals of certain Asian ethnicities, according to a pooled analysis of studies from Asia.

“In the overall sample, no significant associations between kidney function and CKD with POAG were observed. However, significant associations were observed in the combined subgroups of Chinese and Koreans, suggesting that such association may only be present in East Asians specifically,” said the researchers.

The researchers examined data from nine population-based studies – comprising 28,925 individuals (57,340 eyes) from China, Hong Kong, India, Korea, Russia, and Singapore – included in the Asian Eye Epidemiology Consortium. Of these, 856 were determined to have POAG (mean age 64.2 years, 50.6 percent male, mean estimated glomerular filtration rate [eGFR] 78.2 mL/min/1.73 m2, 18.2 percent with CKD [eGFR <60 mL/min/1.73 m2]). They were compared with the 28,069 individuals without POAG (mean age 56.1 years, 45.9 percent male, mean eGFR 86.5 mL/min/1.73 m2, 9.8 percent with CKD).

Overall, decreasing eGFR was not associated with POAG (adjusted odds ratio [adjOR], 1.01, 95 percent confidence interval [CI], 0.96–1.05 for every 10 mL/min/1.73 m2 reduction in eGFR; p=0.769). There was also no association between CKD and POAG (adjOR, 1.04, 95 percent CI, 0.84–1.27; p=0.729). [Br J Ophthalmol 2020;doi:10.1136/bjophthalmol-2019-314890]

Pooled analysis found no link between reduced eGFR (β, -0.02 per 10 mL/min/1.73 m2 decrease; p=0.118) or CKD (β, -0.04; p=0.533) with intraocular pressure (IOP).

When assessed by individual study, there was a significant association between reduced eGFR and POAG in the Singapore Chinese Eye Study (OR, 1.20; p=0.019), specifically among individuals with diabetes (OR, 1.44; p=0.001) or hypertension (OR, 1.21; p=0.014), while CKD was linked to POAG  in individuals with diabetes (OR, 4.15; p=0.016). In the Central India Eye and Medical Study, eGFR was associated with POAG among individuals with hypertension (OR, 1.17; p=0.049).

In contrast to the overall findings, subgroup analysis of Korean and Chinese participants (combined) showed a significant association between reduced eGFR and POAG (OR, 1.09 per 10 mL/min/1.73 m2 decrease; p=0.048). Likewise, severe decline in kidney function, defined as eGFR <45 mL/min/1.73 m2, was associated with POAG (OR, 2.57; p=0.004). Among Chinese and Korean patients with diabetes, CKD (OR, 2.09; p=0.032), severe decline in kidney function (OR, 4.88; p=0.002), and reduced eGFR (OR, 1.23; p=0.003) were factors associated with POAG.

“This finding may indicate that the association between poorer kidney function and POAG may be specific to Korean and Chinese individuals,” said the researchers, noting that this finding could be confirmed by examining the CKD-POAG association in the Japanese population. In addition, studies in Western populations could identify whether ethnicity plays a role in the kidney function-POAG association.

“[These findings suggest that] regular glaucoma screening among individuals with kidney disease may be more beneficial for specific East Asian ethnicities, rather than wide implementation for the whole Asian population,” they noted.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Jairia Dela Cruz, 3 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.
3 days ago
Use of thyroid hormone therapy does not seem to protect older adults with subclinical hypothyroidism against mortality, but it appears to confer survival benefits to those aged <65 years, results of a study have shown.