Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.

Kidney disease severity tied to balance problems

26 Nov 2019

Increasing severity of chronic kidney disease (CKD) and worsening status of 25-hydroxyvitamin D (25(OH)D) appear to increase the likelihood of reporting balance and falling issues, a recent study has found.

Accessing the 1999–2004 dataset of the National Health and Nutrition Examination Survey, researchers evaluated the effects of CKD severity on balance measures, including timed 20-feet walk, Romberg standing balance task, and self-reported balance and falling problems. A total of 8,554 participants (aged >40 years) were enrolled.

Increasing CKD severity was associated with greater rates of falling while standing on a firm surface with eyes open. The normal-function and stage-1/2 controls, for instance, fell 0 percent of the time. This rate rose to 1 percent and 3 percent in the stage 3A/B and stage 4/5 groups, respectively. The difference between the highest and lowest disease severity groups was statistically significant (p=0.02).

The most difficult balance scenario involved participants standing on a foam surface with their eyes closed. A similar pattern emerged: Failure rates grew from 54 percent in controls to 76 percent and 85 percent in the stage 3A/B and stage 4/5 patients, respectively.

The motor deficits associated with disease severity were confirmed in the walking test, which those with stage 3A/B and stage 4/5 disease patients took longer to complete, as compared with their control counterparts.

Patients suffering from more severe CKD were also significantly more likely to report experiencing dizziness, balance difficulties and issues with falling in the past year.

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
Roshini Claire Anthony, 6 days ago

The presence of pulmonary arterial hypertension (PAH) in individuals with systemic sclerosis is associated with an increased mortality risk, a study from Singapore showed.

01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.
23 Dec 2019
At a Menarini-sponsored symposium held during the Asian Pacific Society Congress, renowned cardiologist Prof John Camm provided the latest evidence for chronic stable angina with or without concomitant diseases, with a special focus on the antianginal agent ranolazine and combination therapies. The event was chaired and moderated by Dr Dante Morales from the University of the Philippines College of Medicine.