Most Read Articles
04 Oct 2018
A week of preoperative oral antibiotics prior to percutaneous nephrolithotomy does not appear to confer any benefit in patients at low risk for infectious complications, suggests a recent study. Perioperative antibiotics according to the American Urological Association (AUA) Best Practice Statement is deemed sufficient.
09 Oct 2018
The use of statins does not appear to influence the immature platelet count in patients with coronary artery disease (CAD), a new study has shown.
Rachel Soon, 01 Sep 2018

MIMS Pharmacist presents an overview of a standardized extract of Pinus pinaster bark, and its potential role in slowing down the progression of diabetic retinopathy.

Dr. Lau Hui Ling, 01 Aug 2017
Oral contraceptive selection should be individualized for each patient to yield maximum benefit.

Ixekizumab confers efficacy for up to 4 years in moderate-to-severe psoriasis

01 Aug 2018

It appears that the efficacy of ixekizumab treatment in patients with moderate-to-severe psoriasis lasts for up to 4 years, according to a phase II study.

The investigators performed analysis by last observation carried forward involving patients who received ixekizumab 120 mg and then 80 mg subcutaneously once every 4 weeks.

Ninety-three percent of the patients who completed the randomized placebo-controlled trial entered the open-label extension (OLE). There was a 75-percent decrease in the Psoriasis Area Severity Index score in 82 percent of patients at week 208 of the OLE.

Sixty-four percent of patients had a static Physician Global Assessment score of 0 or 1, and 45 percent had a score of 0 at week 208. Compared with baseline, a decrease was observed in the patients’ Dermatology Life Quality Index and Itch visual analogue scale scores. There were also improvements in other efficacy and health outcome measures.

Serious adverse events (AE) were reported in 16.7 percent of patients, and 87 percent had one or more treatment-emergent AE. Serious infections occurred in three patients, while one patient reported two major cardiovascular events.

This study was limited by the lack of a placebo or active comparator, and it was also unblinded.

A previous phase III trial (UNCOVER-3) has found that ixekizumab is well tolerated and yields persistent efficacy through 108 weeks. [J Am Acad Dermatol 2017;77:855-862]

“Ixekizumab has demonstrated improvement in patients with moderate-to-severe psoriasis by selectively targeting interleukin-17A, which is a proinflammatory cytokine that is important in the pathogenesis of psoriasis,” the investigators said.

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Most Read Articles
04 Oct 2018
A week of preoperative oral antibiotics prior to percutaneous nephrolithotomy does not appear to confer any benefit in patients at low risk for infectious complications, suggests a recent study. Perioperative antibiotics according to the American Urological Association (AUA) Best Practice Statement is deemed sufficient.
09 Oct 2018
The use of statins does not appear to influence the immature platelet count in patients with coronary artery disease (CAD), a new study has shown.
Rachel Soon, 01 Sep 2018

MIMS Pharmacist presents an overview of a standardized extract of Pinus pinaster bark, and its potential role in slowing down the progression of diabetic retinopathy.

Dr. Lau Hui Ling, 01 Aug 2017
Oral contraceptive selection should be individualized for each patient to yield maximum benefit.