Most Read Articles
22 hours ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 4 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
2 days ago
Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
Yesterday
Middle-aged Caucasian men who are dissatisfied with their marriage are at higher risk of sudden cardiac death regardless of other cardiovascular risk factors, a new study reports.

Ixazomib-cyclophosphamide-dexamethasone combo effective for multiple myeloma

10 Aug 2018

The combination of ixazomib, cyclophosphamide and dexamethasone is well-tolerated and effective for newly diagnosed myeloma, a recent study has shown.

The phase 1/2 study included 48 patients newly diagnosed with multiple myeloma (median age 64.5 years; 52.1 percent male), of whom 45 (median age 64.0; 53.3 percent male) subsequently received the phase 2 dose. The maximum tolerated dose and the rate of complete or very good partial responses (VGPR) were the primary endpoints for the first and second phases of the study, respectively.

Majority of the patients (77 percent; n=37) reported at least a confirmed partial response, with 35 percent achieving a VGPR or better. The median time to response was 1.9 months, and the depth of response increased as participants received more cycles of therapy. The overall response rate at the end of four cycles was 71 percent.

The median progression-free (PFS) and overall (OS) survival were not reached for the whole study sample, while the 18-month PGS and OS rates were 81 percent and 96 percent. The 1-year OS was 100 percent.

Over a median of seven therapy cycles, 100 percent of the participants reported at least one adverse event of any grade. Grade 3 or 4 adverse events that were considered to be at least potentially associated to the therapy was observed in 88 percent of the participants.

The most common grade 2 adverse event included nausea, anaemia, neutropoenia, leukopoenia and lymphopoenia.

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Most Read Articles
22 hours ago
Use of potassium citrate and thiazides appears to improve health-related quality of life (HRQOL) among stone formers across all Wisconsin Stone Quality of Life (WISQOL) domains without increasing the likelihood of gastrointestinal complaints and fatigue or sexual complaints, respectively, reports a study.
Pearl Toh, 4 days ago
First-line therapy with the BTK* inhibitor ibrutinib plus the anti-CD20 immunotherapy rituximab confers significant survival advantage over the current gold-standard regimen of fludarabine, cyclophosphamide, and rituximab (FCR) for young, fit patients with treatment-naïve chronic lymphocytic leukaemia (CLL), according to the E1912 trial, a large cooperative group study supported by the US National Cancer Institute.
2 days ago
Eating high amounts of red and processed meat prior to a diagnosis of colorectal cancer appears to be associated with shorter survival time, although a possible weak association cannot be excluded, a study has shown.
Yesterday
Middle-aged Caucasian men who are dissatisfied with their marriage are at higher risk of sudden cardiac death regardless of other cardiovascular risk factors, a new study reports.