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IVZ therapy increases treatment-free interval in nonresponsive eyes with nAMD

27 Dec 2017

Use of intravitreal ziv-aflibercept (IVZ) therapy improves treatment-free interval in eyes with neovascular age-related macular degeneration (nAMD) that are nonresponsive to bevacizumab and ranibizumab, a recent study has shown. However, no significant change in visual and anatomic outcomes has been observed.

IVZ therapy provided no change in the mean logarithm of minimum angle of resolution (logMAR) best corrected visual acuity (BCVA) at baseline and following treatment (p=0.978). Mean IVZ injections during 12 months was 5.9±3.3, and the mean number of antivascular endothelial growth factors (VEGFs) injections prior to switching to IVZ was 8.4±4.7.

Mean treatment-free interval was longer during IVZ therapy compared with days prior to IVZ therapy (114.4±67.1 vs 76.3±54.6 days; p=0.03). Visual gains of at least 0.1 logMAR were achieved in five eyes (31.25 percent), while three eyes (18.75 percent) had stable BCVA (within 0.1 logMAR) and eight eyes (50 percent) had BCVA decline of at least 0.1 logMAR.

Mean changes in central macular thickness (CMT), retinal pigment epithelial detachment (RPED) heights, and presence of subretinal (SRF) and intraretinal fluid (IRF) were not significant at 12 months vs baseline. Additionally, there were no adverse events reported.

Researchers included 16 eyes of 14 patients with nAMD who were on prior treatment with bevacizumab and ranibizumab in this retrospective study. All eyes were treated with as-needed IVZ (1.25 mg/0.05 mL) for 12 months.

The mean change in BCVA was the primary outcome measure, and secondary outcome measures included mean change in CMT, RPED heights, longest treatment-free interval, presence of SRF and IRF, and adverse events.

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Most Read Articles
15 Sep 2018
Prenatal and postpartum vitamin D supplementation does not appear to improve foetal or infant growth, a study reports.
13 Sep 2018
Excessive daytime sleepiness appears to increase the long-term risk of amyloid β (Aβ) deposition, a recent study has shown.
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The causes, presentations and management of anaphylaxis vary considerably with age, according to a recent Singapore study, which reported that children are more likely to present with food anaphylaxis, while drug anaphylaxis is more common in adults.
13 Sep 2018
Substituting diets high in carbohydrates with those high in monounsaturated fatty acids in the context of low saturated fatty acids do not appear to yield favourable effects on blood pressure, according to a meta-analysis.