Most Read Articles
Dr. Joseph Delano Fule Robles, 04 Sep 2017

A recent genome-wide association study (GWAS) performed by investigators from the Chinese University of Hong Kong (CUHK) has found potential new indications for existing drugs for the treatment of various psychiatric disorders. 

04 Mar 2020
At 150-mg doses, oral pregabalin appears to be effective for premature ejaculation, increasing intravaginal ejaculation latency time, a recent study has found.
Pearl Toh, 19 Mar 2020
The lower 0.25 mg/kg dose of the thrombolytic tenecteplase may be sufficient for reperfusion of blocked vessels prior to thrombectomy in patients with ischaemic stroke due to large-vessel occlusion compared with the 0.4 mg/kg dose, according to the EXTEND-IA TNK* Part 2 study presented at the ISC 2020 Meeting.
Roshini Claire Anthony, 6 days ago

The eicosapeptide nerinetide did not improve outcomes in patients with large vessel occlusion-related acute ischaemic stroke who underwent endovascular thrombectomy (EVT). However, patients not treated with alteplase appeared to derive some benefit, results from the multinational ESCAPE-NA1* trial showed.

Isradipine fails to slow Parkinson’s disease progression

Roshini Claire Anthony
15 May 2019

Use of the antihypertensive drug isradipine did not reduce the progression of Parkinson’s disease, according to the STEADY-PD III* study presented at the American Academy of Neurology annual meeting (AAN 2019).

“Unfortunately, the people who were taking isradipine did not have any difference in their Parkinson’s symptoms over the 3 years of the study compared to the people who took a placebo,” said study author Professor Tanya Simuni, chief of movement disorders at the Department of Neurology, Northwestern University Feinberg School of Medicine in Chicago, Illinois, US.

Participants in this phase III study conducted at 54 sites in the US and Canada were 336 patients (mean age 62 years, 68 percent male, mean Unified Parkinson Disease Rating Scale [UPDRS] part I–III score, 23.1) newly diagnosed with Parkinson’s disease (mean 0.9 years since Parkinson’s disease diagnosis) who were randomized 1:1 to receive the dihydropyridine calcium channel antagonist isradipine at a dose of 10 mg/day or placebo for 36 months.

At 36 months, there was no difference in the UPDRS part I–III score between patients who received isradipine and placebo (mean change from baseline, 2.99 vs 3.26 points, treatment effect, 0.27 points, 95 percent confidence interval, -2.5 to 3.0; p=0.85). [AAN 2019, Clinical Trials Plenary Session]

Other secondary endpoints such as time to and need for dopaminergic therapy, time to initial motor complications, changes in non-motor disability, and quality of life were also similar between patients who received isradipine and placebo. The most notable adverse effect among patients who received isradipine was oedema.

The study was undertaken based on previous research that has suggested that calcium channel blockers were associated with a reduced risk of Parkinson’s disease. [Neurology 2008;70(16 Pt 2):1438-1444; Ann Neurol 2010;67:600-606; Am J Epidemiol 2012;175:627-635] Isradipine, specifically, has shown signs of reducing the risk of Parkinson’s disease in animal models. [Neurobiol Dis 2011;43:364-371]

“Of course, this [result] is disappointing news for everyone with Parkinson’s disease and their families, as well as the research community,” said Simuni. “However, negative results are important because they provide a clear answer, especially for [a] drug that is commercially available. We will all continue to work to find a treatment that can slow down or even cure this disease,” she said.

 

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Most Read Articles
Dr. Joseph Delano Fule Robles, 04 Sep 2017

A recent genome-wide association study (GWAS) performed by investigators from the Chinese University of Hong Kong (CUHK) has found potential new indications for existing drugs for the treatment of various psychiatric disorders. 

04 Mar 2020
At 150-mg doses, oral pregabalin appears to be effective for premature ejaculation, increasing intravaginal ejaculation latency time, a recent study has found.
Pearl Toh, 19 Mar 2020
The lower 0.25 mg/kg dose of the thrombolytic tenecteplase may be sufficient for reperfusion of blocked vessels prior to thrombectomy in patients with ischaemic stroke due to large-vessel occlusion compared with the 0.4 mg/kg dose, according to the EXTEND-IA TNK* Part 2 study presented at the ISC 2020 Meeting.
Roshini Claire Anthony, 6 days ago

The eicosapeptide nerinetide did not improve outcomes in patients with large vessel occlusion-related acute ischaemic stroke who underwent endovascular thrombectomy (EVT). However, patients not treated with alteplase appeared to derive some benefit, results from the multinational ESCAPE-NA1* trial showed.