Most Read Articles
23 Oct 2017
Patients with first-episode psychosis (FEP) appear to have lower total and low-density lipoprotein (LDL) cholesterol levels but elevated triglyceride levels, according to a study.
11 Sep 2017
An inverse association exists between systolic blood pressure (SBP) in young adults and depression and anxiety score, independent of a range of lifestyle confounders, according to a recent study. Furthermore, the inverse association between SBP and self-reported history of depression is enhanced by adiposity despite a positive correlation between BP and body mass index (BMI).
Dr. Joseph Delano Fule Robles, 04 Sep 2017

A recent genome-wide association study (GWAS) performed by investigators from the Chinese University of Hong Kong (CUHK) has found potential new indications for existing drugs for the treatment of various psychiatric disorders. 

13 Sep 2017
The likelihood of suicidal ideation, suicide attempts and completed suicides is substantially greater in patients with psoriasis, according to a recent study. Among these patients, those who are younger and whose psoriasis is more severe are at risk of suicidality.

Isotretinoin use for acne may ameliorate depressive symptoms

19 May 2017

It appears that using isotretinoin for acne does not increase the risk for depression, and the treatment of acne seems to improve depressive symptoms, according to a recent study.

To assess the relationship between isotretinoin and depression, researchers conducted a systematic review and meta-analysis of literature published from inception to 30 September 2016. Included were controlled or prospective noncontrolled trials on ≥15 acne patients receiving isotretinoin treatment. The prevalence of depression and change in depression scores were calculated.

There were 31 studies that met the inclusion criteria. In the controlled studies, no significant difference was seen in the change in depression scores from baseline between patients receiving isotretinoin treatment and those receiving an alternative treatment (standardized mean difference [SMD], ‒0.334; 95 percent CI, ‒0.680 to 0.011).

After treatment with isotretinoin, the prevalence of depression declined (relative risk, 0.588; 0.382 to 0.904). The mean depression scores significantly decreased from baseline (SMD, ‒0.335; ‒0.498 to ‒0.172).

A previous systematic review found that studies comparing depression before and after isotretinoin treatment did not show a statistically significant increase in depression diagnoses or depressive symptoms. Moreover, some studies showed a trend toward fewer or less severe depressive symptoms after isotretinoin therapy. There was also no association between isotretinoin use and suicidal behaviour, although only one retrospective study presented data on this topic. [Semin Cutan Med Surg 2005;24:92-102]

The current study had some limitations. Researchers did not review randomized controlled trials, and a large interstudy variation was observed.

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Most Read Articles
23 Oct 2017
Patients with first-episode psychosis (FEP) appear to have lower total and low-density lipoprotein (LDL) cholesterol levels but elevated triglyceride levels, according to a study.
11 Sep 2017
An inverse association exists between systolic blood pressure (SBP) in young adults and depression and anxiety score, independent of a range of lifestyle confounders, according to a recent study. Furthermore, the inverse association between SBP and self-reported history of depression is enhanced by adiposity despite a positive correlation between BP and body mass index (BMI).
Dr. Joseph Delano Fule Robles, 04 Sep 2017

A recent genome-wide association study (GWAS) performed by investigators from the Chinese University of Hong Kong (CUHK) has found potential new indications for existing drugs for the treatment of various psychiatric disorders. 

13 Sep 2017
The likelihood of suicidal ideation, suicide attempts and completed suicides is substantially greater in patients with psoriasis, according to a recent study. Among these patients, those who are younger and whose psoriasis is more severe are at risk of suicidality.