Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

4 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.

Isoniazid preventive therapy safe, effective against TB in pregnant women with HIV

17 Feb 2020

Isoniazid preventive therapy (IPT) is safe to use in pregnant women with HIV, especially those with a CD4 count <350 cells/μl, conferring protection against incident tuberculosis (TB) without deleterious maternal and foetal consequences, a study has shown.

Researchers looked at the medical records of a cohort of pregnant women living with HIV (n=43,971; mean age, 29.8 years) and who had received antiretroviral therapy prior to and/or during the index pregnancy. IPT was dispensed to 16.6 percent of the population at some point after conception. Median duration of IPT was 168 days, while median duration of antenatal exposure was 124 days.

Compared with those who did not receive IPT, women on IPT had lower odds of experiencing poor pregnancy outcomes (adjusted odds ratio [aOR], 0.83, 95 percent confidence interval [CI], 0.78–0.87).

The beneficial effect on pregnancy outcomes was notably pronounced when IPT was initiated after the first trimester (aOR, 0.71, 95 percent CI, 0.65–0.79) or during the first trimester (aOR, 0.64, 95 percent CI, 0.55–0.75).

IPT cut the risk of TB by about 30 percent (adjusted hazard ratio [aHR], 0.71, 95 percent CI, 0.63–0.81; absolute risk-difference, 1,518/100,000 women). The effect was modified by CD4 count, such that the protective effect was greater if CD4 count was ≤350 cells/μl (aHR, 0.51, 95 percent CI, 0.41–0.63) than if the count was >350 cells/µl (aHR, 0.93, 95 percent CI, 0.76–1.13).

The findings indicate that antenatal IPT provides protection against TB up to 12 months postpartum, according to the researchers. The strategy also appears to be safe, even reducing the risk of poor pregnancy outcomes such as miscarriage, stillbirth and low birthweight, among others.

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Most Read Articles
Roshini Claire Anthony, 29 May 2020

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

4 days ago
Use of corticosteroid is not associated with improved outcomes in idiopathic pulmonary fibrosis (IPF) patients admitted to the hospital with acute exacerbation (AE), reveals a recent study. In addition, corticosteroids may even contribute to reduced overall survival following exacerbation.
Dr. Wong Soon Tee, 28 May 2020
Acne is a common skin problem seen in primary care. Dr Wong Soon Tee of Assurance Skin Clinic at Mt Elizabeth Novena Hospital, Singapore shares his insights with Pearl Toh on how to manage acne in the primary care setting.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.