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Isolated maternal hypothyroxaemia in third trimester linked to pre-eclampsia

14 Jul 2017
Researchers in China have shown that isolated maternal hypothyroxaemia (IMH) detected during the third trimester of pregnancy is strongly correlated with pre-eclampsia in the first large-scale investigation to undertake long-term monitoring of free thyroxin (FT4) levels in Chinese mothers with hypothyroxaemia.

In the study, first (week 9–12) and third (week 32–36) trimester serum samples were collected from 6,031 mothers (aged 21–43 years) for analyses of thyroid function. All of the women had singleton pregnancies, were Han Chinese, had no history of thyropathy or autoimmune disease, no goiters, were thyroid peroxidase antibody (TPOAb)-negative, and did not use medicines that would affect thyroid hormone levels. In addition, all had TSH levels within the reference intervals during the first and third trimesters of pregnancy. Women were monitored for adverse pregnancy outcomes such as gestational diabetes mellitus (GDM), pregnancy-induced hypertension, and pre-eclampsia.

The researchers found that women who were older and those who had a higher pre-pregnancy body mass index were more likely to experience hypothyroidism. Although pregnancy-induced hypertension was not significantly correlated with FT4, GDM, and pre-eclampsia were inversely correlated with maternal FT4 levels during early and late pregnancy, respectively. In particular, women with IMH during the third trimester had an increased risk of developing pre-eclampsia.
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Most Read Articles
3 days ago
Combining the DASH (Dietary Approaches to Stop Hypertension) diet with low sodium intake reduces systolic blood pressure (SBP) in individuals with pre- and stage 1 hypertension, with progressively higher reductions at greater levels of baseline SBP, a recent study has shown.
Tristan Manalac, Yesterday
Major depressive disorder (MDD) appears to be more prevalent in females than in males, particularly in those who are divorced or widowed, a recent study from Singapore has found.
6 days ago
Cognitive deficits in bipolar disorder are neurodevelopmental rather than neurodegenerative in nature, a recent study has reported. Furthermore, cognitive impairment in bipolar patients appears to be stable, in the majority at least.
3 days ago
Tadalafil may not be effective for reducing the decline in ambulatory ability in boys with Duchenne muscular dystrophy (DMD), as shown in a recent study.