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01 Jul 2013

Acne is particularly prevalent during adolescence, and some teenagers will face an on-going battle with this common skin condition.

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Is there a histopathologic difference between palmar psoriasis and hand eczema?

16 Jul 2017

There is a marked difference in the thickness of the granular layer between palmar psoriasis and hand eczema, and this may be helpful in differentiating between the two skin conditions, according to a recent study.

Additionally, no significant difference exists between palmar psoriasis and hyperkeratotic hand dermatitis (HHD).

Researchers sought to distinguish the histopathologic differences among palmar psoriasis, hand eczema and HHD, which have been poorly characterized. They conducted a retrospective analysis of the histology of hematoxylin-eosin‒stained sections obtained from patients (n=96) with palmar psoriasis, hand eczema or HHD.

The participants were divided into four subgroups: palmar psoriasis (n=16; group A), hand eczema without atopic or nummular dermatitis (n=41; group B), hand eczema with atopic or nummular dermatitis (n=14; group C), and HHD (n=25; group D).

Patients diagnosed with palmar psoriasis (p=0.047) had a more consistent loss of the granular layer (group A, 62.5 percent; group B, 24.4 percent; group C, 0 percent) than hand eczema patients (p=0.002). Psoriasiform epidermal hyperplasia (group B, 36.6 percent; group C, 35.7 percent; group D, 72.0 percent) favoured a diagnosis of HHD (p=0.01) over hand eczema (p=0.043).

This study is limited by its retrospective design and small sample size, according to researchers.

A previous study reported that the relationship between clinical type of hand eczema and aetiological diagnosis fitted with general experience, but there was no simple relationship observed, emphasizing that patch testing and exposure analysis are mandatory. Furthermore, researchers identified hyperkeratotic palmar hand eczema as a distinct clinical subtype. [Contact Dermatitis 2011;65:13-21]

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Most Read Articles
01 Jul 2013

Acne is particularly prevalent during adolescence, and some teenagers will face an on-going battle with this common skin condition.

27 Apr 2017
Lifestyle and physiological factors determine the wrinkling patterns between men and women, a recent study suggests. Less wrinkling is associated with sunburn tendency in men and with female pattern hair loss in women, whereas increased wrinkling is linked to age and current smoking in both genders.
01 Jul 2014

New drug applications approved by US FDA as of 1-15 July which includes New Molecular Entities (NMEs) and new biologics. It includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

01 Mar 2017
The use of multiple dissection planes in endoscope-assisted facelifts of the frontal and temporal areas may be helpful for selected patients, a Singapore study reveals.