Most Read Articles
6 days ago
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
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Women with central adiposity, regardless of menopausal status, are at risk of developing breast cancer, according to a study.

Is dialysis unavoidable in patients with advanced lupus nephritis-related CKD?

09 Sep 2020

Advanced chronic kidney disease (CKD) associated with lupus nephritis (LN) does not necessarily lead to a need for dialysis, suggests a study, which shows majority of its patients (62 percent) not progressing over 10 year of follow-up on average.

“Advanced CKD carries an increased risk for progression to end-stage renal disease (ESRD),” said the investigators, who sought to determine the progression rate and factors that drove the decline of renal function in LN.

The study included patients with advanced LN-related CKD from a long-term longitudinal cohort. Advanced CKD was characterized by stage 3b (estimated glomerular filtration rate [eGFR], 30–44 ml/min/1.73 m2) and stage 4 (eGFR, 15–29 ml/min/1.73 m2).

The investigators followed all patients until progression to ESRD or the last visit and divided them into “progressors” and “nonprogressors.” They also compared demographic, clinical, immunological, and therapeutic variables at baseline. Predictors for progression were identified by performing multivariable Cox regression analysis (both time-dependent and independent).

Of the 118 patients (74 CKD 3b and 44 CKD 4) included, 45 progressed (29 to ESRD and 16 from CKD 3b to CKD 4) after 6 years on average. Seventy-three patients (nonprogressors) showed no significant decline in renal function after 10 years on average.

Certain predictors for progression to ESRD were also identified. Active serology (high anti-dsDNA titres and low complements C3/C4) at the time of CKD diagnosis and any increase of the daily prednisone dose after baseline showed a robust correlation with progression. On the other hand, treatment with renin angiotensin system blockers correlated with less risk for progression.

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Most Read Articles
6 days ago
Regular practice of yoga postures confers benefits for glucose control, oxidative stress, inflammatory response, and sleep quality in patients with type 2 diabetes, a study has found.
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
6 days ago
Women with central adiposity, regardless of menopausal status, are at risk of developing breast cancer, according to a study.