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12 Jun 2019
Urogenital infections remain a major reason for women to visit their family physician and their subsequent referral to obstetrics and gynaecology or urology specialists. The association between abnormal vaginal microbiota and an increased risk of contracting sexually transmitted diseases (STDs), as well as an increased rate of preterm labour, indicates the need to better understand and manage urogenital health in women. Probiotics are “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host”. As such, there is a sound rationale for using probiotics to maintain female vaginal and bladder health.
Audrey Abella, 27 Mar 2020
The angiotensin receptor blocker (ARB) losartan did not improve inflammation, T-cell immune recovery, or fibrotic activity among older persons living with HIV (PLHIV) and viral suppression, according to data presented at CROI 2020.

Is cephalosporin still beneficial in paediatric UTI?

03 Feb 2020

Clinical outcomes are comparable between paediatric patients receiving appropriate (AT) and inappropriate empirical therapy (IAT) for the treatment of urinary tract infection (UTI), reports a study.

A total of 151 patients met the eligibility criteria. Escherichia coli was the most common causative organism: 88.8 percent in the AT group and 96.2 percent in the IAT group. Among these causative organisms, 19.8 percent were extended-spectrum beta-lactamase-producing organisms.

No significant difference was found between the AT and IAT groups regarding clinical failure, microbiologic failure, relapse or time to defervescence. Sepsis did not develop in any of the patients in either group following empirical therapy. However, those who received IAT had significantly longer hospital stay than those treated with AT (4.00 vs 7.00 days, respectively; p=0.000).

“In the era of increasing antimicrobial resistance, third-generation cephalosporins may still be a good choice as an empirical antimicrobial for children diagnosed with community-onset UTI,” the investigators suggested.

This retrospective cohort study involved paediatric patients with first-episode community-onset UTI caused by E. coli, Klebsiella pneumoniae and Proteus spp. at Ramathibodi Hospital from 2011 to 2017. Patients were classified into IAT and AT groups, and clinical outcomes were examined by reviewing the medical records.

“UTI is a common cause of fever in children,” the investigators said. “Despite the increasing numbers of extended-spectrum beta-lactamase-producing organisms in the community, the empirical therapy of choice is still third-generation cephalosporins.”

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Most Read Articles
12 Jun 2019
Urogenital infections remain a major reason for women to visit their family physician and their subsequent referral to obstetrics and gynaecology or urology specialists. The association between abnormal vaginal microbiota and an increased risk of contracting sexually transmitted diseases (STDs), as well as an increased rate of preterm labour, indicates the need to better understand and manage urogenital health in women. Probiotics are “live microorganisms which, when administered in adequate amounts, confer a health benefit on the host”. As such, there is a sound rationale for using probiotics to maintain female vaginal and bladder health.
Audrey Abella, 27 Mar 2020
The angiotensin receptor blocker (ARB) losartan did not improve inflammation, T-cell immune recovery, or fibrotic activity among older persons living with HIV (PLHIV) and viral suppression, according to data presented at CROI 2020.