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Iron supplements may reduce SBP in LBW children at 7 years

07 Aug 2017
Nurse moms who feel more equipped in managing their children’s moods will create a happier environment for them to thrive in.

Iron supplementation (1 or 2 mg Fe · kg−1· d−1) in low birth weight (LBW) children during infancy is associated with lower systolic blood pressure (SBP) at 7 years, a recent study has found.

To examine the effect of iron supplementation given to LBW infants on midchildhood BP, researchers conducted a randomized, double-blind, controlled trial including 285 marginally LBW (2,000 to 2,500 g) infants at two Swedish centres between May 2004 and November 2007.

Participants were randomly assigned to receive either placebo or 1 or 2 mg Fe · kg−1 · d−1 from 6 weeks to 6 months of age. Researchers then compared SBP, diastolic (D)BP and the prevalence of children with BP within the hypertensive range (>90th percentile) between the groups in secondary analyses at the age of 7 years.

Intention-to-treat analysis of BP was performed in 189 children (66 percent).

LBW children who received placebo (n=70), 1 mg Fe · kg−1 · d−1 (n=54) or 2 mg Fe · kg−1 · d−1 (n=65) had mean SBP of 103±8.1, 101±7.5 and 101±7.8 mm Hg, respectively. Combining the iron-supplemented group in covariate-adjusted analyses showed that children who received iron supplementation in infancy had a mean SBP of 2.2 mm Hg (95 percent CI, 0.3 to 4.2 mm Hg) lower than in those who did not receive supplementation (p=0.026).

Based on multivariate logistic regression analysis, the odds of having an SBP within the hypertensive range at the age of 7 years were reduced with iron supplementation in infancy (odds ratio, 0.32; 0.11 to 0.96). No significant differences in DBP were observed between the intervention groups.

“This novel observation [to our knowledge] suggests that the increased risk of hypertension that is observed in children and adults who are born small might be reduced with early micronutrient interventions,” researchers said.

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Most Read Articles
Pearl Toh, 13 Apr 2018
Impaired endothelial-dependent microvascular reactivity appears to be predictive of albuminuria progression in Asian patients with type 2 diabetes (T2D) who have normal urine albumin levels at baseline, but not in those with microalbuminuria, a prospective longitudinal cohort study suggests.
28 Dec 2017
Varenicline, while effective for smoking cessation, appears to significantly elevate the risk of cardiovascular hospitalization and emergency department visits, particularly for new users, a recent study shows.
26 Jan 2018
In children, a short duration of sleep appears to be a significant risk factor for elevated cardiometabolic risk, suggesting that parents need to be mindful of their children’s sleep hygiene, a recent Spanish study has shown.
21 Dec 2017
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