Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 4 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.

Iron supplements during pregnancy have minimal effect on postpartum haemoglobin

23 Nov 2019
Many pregnant women require routine medication, but there is a critical shortage of information regarding the safety and efficacy of regular medicine for this specific demographic.

Iron-folic acid (IFA) or multiple micronutrient (MMN) supplementation in pregnant women with or without mild anaemia does not seem to bear significant benefit, reports a recent study.

Researchers conducted a double-blind randomized controlled trial including 18,775 nulliparous women who were assigned to receive 400 µg of daily FA (n=5,765; mean age, 23.6±2.9 years), IFA (n=5,779; mean age, 23.6±2.8 years) or MMNs (n=5,734; mean age, 23.6±2.8 years). Supplements were taken from before 20 weeks of gestation until delivery.

Mean gestational weight gain was 12 kg and was statistically comparable across the supplementation groups. Upon enrolment, 70–71 percent of participants had haemoglobin levels from 110–130 g/L, 23–24 percent had haemoglobin concentrations >130 g/L, and 5–6 percent had levels <110 g/L.

After giving birth, haemoglobin concentrations remained comparable across the FA, IFA and MMN groups (123.6 vs 123.8 vs 123.9 g/L, respectively). None of the pairwise comparisons resulted in statistical significance. The prevalence of maternal anaemia was likewise similar across intervention groups postpartum (27.2 percent vs 26.8 percent vs 26.3 percent, respectively).

Further disaggregating according to baseline haemoglobin concentrations did not change the principal findings. None of the supplements used led to significant improvements in postpartum haemoglobin in any of the baseline haemoglobin groups.

Similar results were reported for infant outcomes. Mean haemoglobin levels at 6 months of age were comparable between the FA, IFA and MMN supplement groups (121.7 vs 121.7 vs 121.8 g/L, respectively). The same was true for the prevalence of anaemia (6.9 percent vs 6.7 percent vs 6.7 percent, respectively).

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Most Read Articles
01 Dec 2019
Macrolide antibiotics are derived from the Streptomycesspecies. These contain either 14-membered (erythromycin [ERM],clarithromycin [CAM], roxithromycin [RXM]), 15-membered(azithromycin [AZM]) or 16-membered (spiramycin, josamycin,midecamycin) macrocyclic lactone rings. They inhibit proteinsynthesis by reversibly binding to the 23S ribosomal RNA (rRNA)in the 50s subunit of the bacterial ribosome. Traditionally,macrolides are used as first-line agents in respiratory, skin,soft tissue, and urogenital infections, and they are also activeagainst gram-positive cocci and atypical pathogens.
29 Nov 2019
Metformin Extended Release 500 mg,750 mg, and 1000 mg
Jairia Dela Cruz, 4 days ago
Nonsmall cell lung cancer (NSCLC) patients harbouring sensitive EGFR mutations may fare well with the third-generation tyrosine kinase inhibitor osimertinib as an upfront therapy, with the results of a network meta-analysis showing that the drug tops other currently available options in terms of progression-free survival and tolerability.
01 Dec 2019
Pneumonia is a common infection– affecting around 3,200 people inSingapore in 2016 – making it the thirdmost common cause of hospitalisation inthe country. Its common complications,especially with delayed or inappropriatetreatment, include bacteraemia andseptic shock, lung abscesses, pleuraleffusions, empyema, pleurisy, respiratoryfailure and renal failure.