Most Read Articles
11 Nov 2019
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
11 Nov 2019
Multiple intralesional injections with purified protein derivative (PPD) leads to faster clearance of common warts compared with a single injection, although the latter is better tolerated, as shown in the results of an open‐label, superiority trial.
17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.
Rachel Soon, 5 days ago

The third Pharmaceutical Industry Pharmacists Insight (PIPI 3.0) symposium will highlight areas of the pharmaceutical industry often overlooked by those entering the pharmacy profession.

Ipratropium, salmeterol show therapeutic potential in multiple sclerosis

25 Sep 2019

Use of both ipratropium and salmeterol is associated with reduced likelihood of being diagnosed with multiple sclerosis (MS), according to a study, suggesting that the drugs may help prevent or stop the development of the disease in its early stages.

Researchers conducted a matched case–control study that examined the effect of exposure to ipratropium and salmeterol over the past 2 years between patients with MS (n=214) and matched general outpatients (control; n=2,164).

The mean age of the entire population was 41 years. Compared with controls, MS patients are more likely to be current smokers (34.6 percent vs 20.2 percent) and have a family history of MS (9.2 percent vs 0.5 percent) but had a lower prevalence of chronic pulmonary disease (0.9 percent vs 5.4 percent).

Prescriptions of ipratropium and salmeterol were consistently fewer in the MS vs control group in the past 1, 2 and 3 years before the index date. In multivariable Poisson regression model, prescriptions of either ipratropium or salmeterol in the past 2 years were higher by 3.2 (95 percent CI, 1.4–7.1; p=0.006) in the control group than in the MS group.

In the generalized structural equation model, use of ipratropium and salmeterol was strongly associated with reduced MS incidence (p=0.036), whereas smokers and individuals with family history of MS were more likely to be diagnosed with the disease (p<0.001).

The present data provide a platform for personalized medicine for high-risk populations of MS by tailoring treatments based on lifestyle and environmental factors, the researchers said. The next step in the research is to develop a randomized clinical trial evaluating ipratropium and salmeterol as a treatment option for patients with MS.

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Most Read Articles
11 Nov 2019
Older women with longer endogenous oestrogen exposure and hormone therapy use are at much higher odds of having favourable cognitive status in late life, a recent study suggests.
11 Nov 2019
Multiple intralesional injections with purified protein derivative (PPD) leads to faster clearance of common warts compared with a single injection, although the latter is better tolerated, as shown in the results of an open‐label, superiority trial.
17 Oct 2019
Use of direct acting antivirals (DAAs) to treat hepatitis C virus (HCV) infection is feasible during pregnancy, as these drugs are highly effective and treatment duration is relatively short, according to a study. In addition, DAA treatment helps improve maternal health and prevent vertical transmission.
Rachel Soon, 5 days ago

The third Pharmaceutical Industry Pharmacists Insight (PIPI 3.0) symposium will highlight areas of the pharmaceutical industry often overlooked by those entering the pharmacy profession.