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4 days ago
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Ipilimumab therapy may improve survival in uveal, mucosal melanoma

06 Mar 2020

Treatment with ipilimumab appears to increase survival in patients with uveal and mucosal melanoma, according to a multicentre, retrospective study.

Thirty-one patients with uveal (n=20) and mucosal (n=11) melanoma diagnosed between 2010 and 2017 were enrolled in this study. Assessment was performed on the following data: patient characteristics, metastatic disease sites, treatment before ipilimumab therapy, performance status, haemoglobin, lactate dehydrogenase levels, B-RAF and c-kit mutation status, toxicity and survival.

SPSS version 17 was used for statistical analysis and Kaplan-Meier method for survival analysis. For univariate analysis, log-rank test was used. Cox regression analysis was performed to examine the association between multivariate variables and survival.

The median overall survival among patients was 7 months (95 percent confidence interval [CI], 1.1–12.7). Bone metastasis, anaemia, high lactate dehydrogenase level and more metastatic sites correlated with a lower overall survival, but in univariate analysis, a favourable overall survival correlated with better treatment and administration of ipilimumab in first or second lines.

Multivariate analysis revealed that only treatment response status and first- or second-line ipilimumab administration were significantly predictive of survival in these patients.

“Ipilimumab therapy may be associated with increased survival, but [the small number of participants] makes that hard to definitely conclude,” the authors said.

These findings support those of a previous study, which reported efficacy and tolerability of ipilimumab in pretreated patients with uveal and mucosal melanoma similar to those reported in clinical trials. [Med J Aust 2014;201:49-53]

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Most Read Articles
4 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 3 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
Roshini Claire Anthony, 2 days ago

Among patients with nonvalvular atrial fibrillation (AF), treatment with apixaban was associated with a lower rate of ischaemic stroke, systemic embolism, and major bleeding compared with rivaroxaban, according to a large study assessing patients in routine care.

21 hours ago
Exposure to sunlight appears to increase the risk of vulvovaginal candidiasis (VVC) development, reveals a recent study in an African population.