Most Read Articles
Stephen Padilla, 3 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.

6 days ago
Treatment with tradipitant in patients with idiopathic or diabetic gastroparesis produces meaningful improvements in nausea and vomiting, according to the results of a phase II trial.

Ipilimumab therapy may improve survival in uveal, mucosal melanoma

06 Mar 2020

Treatment with ipilimumab appears to increase survival in patients with uveal and mucosal melanoma, according to a multicentre, retrospective study.

Thirty-one patients with uveal (n=20) and mucosal (n=11) melanoma diagnosed between 2010 and 2017 were enrolled in this study. Assessment was performed on the following data: patient characteristics, metastatic disease sites, treatment before ipilimumab therapy, performance status, haemoglobin, lactate dehydrogenase levels, B-RAF and c-kit mutation status, toxicity and survival.

SPSS version 17 was used for statistical analysis and Kaplan-Meier method for survival analysis. For univariate analysis, log-rank test was used. Cox regression analysis was performed to examine the association between multivariate variables and survival.

The median overall survival among patients was 7 months (95 percent confidence interval [CI], 1.1–12.7). Bone metastasis, anaemia, high lactate dehydrogenase level and more metastatic sites correlated with a lower overall survival, but in univariate analysis, a favourable overall survival correlated with better treatment and administration of ipilimumab in first or second lines.

Multivariate analysis revealed that only treatment response status and first- or second-line ipilimumab administration were significantly predictive of survival in these patients.

“Ipilimumab therapy may be associated with increased survival, but [the small number of participants] makes that hard to definitely conclude,” the authors said.

These findings support those of a previous study, which reported efficacy and tolerability of ipilimumab in pretreated patients with uveal and mucosal melanoma similar to those reported in clinical trials. [Med J Aust 2014;201:49-53]

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Most Read Articles
Stephen Padilla, 3 days ago
The novel coronavirus disease (COVID-19) pandemic appears to have a significant impact on oncological care, according to a study, which stresses the need for psycho-oncological support for cancer patients.
01 Aug 2020
Supplementation with probiotics may have positive effects in patients with type 2 diabetes mellitus (T2DM), reports a recent meta-analysis.
Roshini Claire Anthony, 30 Jul 2020

Frailty may indicate an increased risk of death from COVID-19, results of the COPE* study showed.

6 days ago
Treatment with tradipitant in patients with idiopathic or diabetic gastroparesis produces meaningful improvements in nausea and vomiting, according to the results of a phase II trial.