Most Read Articles
Pearl Toh, Yesterday
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 4 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

INVICTUS crossover analysis boosts potential of ripretinib for GIST

Audrey Abella
08 Sep 2020

The novel switch-control tyrosine kinase inhibitor ripretinib delivered a clinically meaningful benefit for patients with gastrointestinal stromal tumours (GISTs) following crossover from placebo, and had a safety profile consistent with that observed in the double-blind phase, according to the results of the crossover analysis of the INVICTUS trial presented at ESMO GI 2020.

“In the double-blind phase, ripretinib reduced the risk of disease progression or death by 85 percent vs placebo and had a favourable overall safety profile,” said the researchers.

The double-blind phase saw 129 patients with advanced GISTs who have previously received imatinib, regorafenib, and sunitinib. Participants were randomized 2:1 to receive ripretinib 150 mg QD or placebo (28-day cycles). Upon disease progression by blinded independent central review, patients entered the open-label phase, wherein 29 placebo recipients (median age 68 years, 55 percent male) crossed over to open-label ripretinib 150 mg QD. [ESMO GI 2020, abstract O-13]

Placebo recipients who crossed over to ripretinib had a median progression-free survival (PFS) of 4.6 months, which was shorter than that observed in the initial ripretinib arm (6.3 months) but longer than in the initial placebo arm (1.0 month).

“Patients [who crossed] over from placebo to ripretinib began to derive benefit as soon as 1 month after starting treatment … [Moreover,] two patients [had] confirmed partial responses after crossing over to ripretinib,” noted Dr César Serrano from the Vall d'Hebron Institute of Oncology in Barcelona, Spain, in his presentation.

In terms of overall survival (OS), placebo recipients who crossed over to ripretinib had a median OS of 11.6 months. As with PFS, this was shorter than that seen in the initial ripretinib arm (15.1 months) but longer than original placebo recipients who did not cross over to ripretinib (1.8 months).

“Placebo recipients who failed to cross over had an increased risk of fatal disease progression,” Serrano said.

No new safety signals were seen in the crossover cohort. As in the double-blind phase, anaemia was the most common grade 3/4 treatment-emergent adverse event (21 percent), followed by fatigue (10 percent) and abdominal pain (7 percent).

“These data suggest that, for patients who were able to cross over, ripretinib established disease control despite delayed initiation of treatment. [H]owever, maximum benefit is achieved when ripretinib is used immediately after failure of prior therapy in patients with ≥4th-line advanced GIST,” said Serrano.

Therefore, these findings underscore the importance of timely treatment in order to achieve improved outcomes with ripretinib in this patient setting, he added.

“[It is] important to remember that a statistically significant and meaningful OS benefit (hazard ratio, 0.36) was demonstrated in the primary analysis despite [a] 65-percent crossover,” commented discussant Professor Sharlene Gill from the University of British Columbia in Vancouver, BC Canada. “[Nonetheless, the] current exploratory analysis affirms that [the] efficacy and safety profile [of ripretinib] were maintained in the crossover cohort.”

While mostly benign, GISTs, if left untreated, account for 1–2 percent of GI malignancies. [J Gastrointest Oncol 2019;10:144-154; Cancer Epidemiol Biomarkers Prev 2015;24:298-302] The FDA has recently granted approval for ripretinib for the treatment of adults with advanced GIST who have received prior treatment with ≥3 kinase inhibitors, including imatinib.

The phase III INTRIGUE study will evaluate ripretinib against sunitinib in patients with advanced GIST following imatinib treatment. Enrolment for this study is underway.

 

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Gastroenterology - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
Pearl Toh, Yesterday
The combination therapy comprising carfilzomib, cyclophosphamide and dexamethasone (KCd) is effective, with a tolerable safety profile, in an Asian cohort with high-risk multiple myeloma (MM) — thus providing a more economical alternative as a potential upfront regimen in resource-limited settings, according to leading experts during a myeloma education webinar.
Audrey Abella, 4 days ago
Extremes of sleep duration (≤5 or ≥10 hours/day), which is a known mortality risk factor in the general population, may increase absolute mortality in adults with type 2 diabetes (T2D), a prospective study has shown.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.