Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Stephen Padilla, 15 Jun 2020
Consumption of whole almonds as snacks not only reduces low-density lipoprotein cholesterol (LDL-C) but also significantly improves endothelial function in adults with above-average risk of cardiovascular disease (CVD), according to the results of a trial.
Pearl Toh, 2 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.

Inulin-type fructans curb rise in gut microbiome-generated indole in patients on peritoneal dialysis

30 May 2020
Intellis system offers transformative dialysis care option

In patients receiving peritoneal dialysis, inulin-type fructan (ITF) intervention limits the increase in gut microbiome-generated indole, suggests a study.

The investigators recruited 21 patients receiving peritoneal dialysis for >3 months without diabetes and not using antibiotics to a randomized, double-blind, placebo-controlled, crossover trial of ITF intervention over 36 weeks, with a 12-week washout period. Fifteen patients completed the study.

The primary outcomes included gut microbiome, faecal indole and p-cresol, indole-producing bacteria, p-cresol-producing bacteria, and serum indoxyl sulphate (IS) and p-cresyl sulphate (pCS). Faecal pH, 24-hour urine, and dialysis removal of IS and pCS were the secondary outcomes.

Daily nutrient intakes, including protein, tryptophan, and tyrosine, were isostatic during the prebiotic, washout, and placebo intervention. No baseline differences were observed in the outcomes between treatment groups.

Concentrations of faecal indole did not significantly change in either treatment, but a trend toward the treatment-by-time effect was seen (p=0.052), with a quantitative reduction in the ITF treatment and an increase in the control. There was a significant difference in the changes between the two treatments (–10.07±7.48 μg/g vs 13.35±7.66 μg/g; p=0.040).

Similar to Bacteroides thetaiotaomicron, a difference was noted over time between treatments, with a substantial treatment and time interaction effect (p=0.047). No treatment, time, or interaction effects were found for faecal p-cresol, serum IS, and pCS, 24-hour urine, and dialysis removal of IC and pCS.

“IS and pCS, two important protein-bound uremic toxins, are independent risk factors for cardiovascular disease in patients with end-stage renal disease,” the investigators said. “Indole and p-cresol are gut microbiome-generated precursors of IS and pCS.”

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Most Read Articles
20 Jun 2020
The Lundbeck Neuroscience Symposium was held at Sofitel KL Damansara over 2 days, with extensivediscussions on the management of various mental illnesses. The second day of the symposiumaddressed the topic of schizophrenia management, focusing on treatment goals, the rationale forpartial dopamine D(2) receptor agonism and the use of long-acting injectable (LAI) antipsychotics topromote adherence.
Stephen Padilla, 15 Jun 2020
Consumption of whole almonds as snacks not only reduces low-density lipoprotein cholesterol (LDL-C) but also significantly improves endothelial function in adults with above-average risk of cardiovascular disease (CVD), according to the results of a trial.
Pearl Toh, 2 days ago
Having migraine during midlife appears to be associated with a higher risk of developing dementia in later life, according to a large population-based longitudinal Danish study presented at the AHS* 2020 Virtual Meeting, indicating that migraine may be a risk factor for dementia.
27 May 2020
The perception that proton pump inhibitors (PPIs) cause multiple serious adverse effects (AEs) is supported by many internists, who then recommend treatment cessation even in patients at high risk for upper gastrointestinal bleeding (UGIB), reveals a study.