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01 Dec 2020
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Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
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Intravitreal conbercept safe, effective against macular oedema secondary to CRVO

07 Aug 2020

Intravitreal conbercept in three monthly loading doses, followed by a pro re nata (PRN) regimen, is safe and effective for patients with macular oedema secondary to central retinal vein occlusion (CRVO), a recent China study has shown.

Researchers enrolled 27 patients (mean age, 52.1±16.1 years; 48 percent male) with macular oedema secondary to CRVO, who contributed 27 eyes for retrospective analysis. Participants were given monthly intravitreal conbercept injections for 3 months, then PRN injections monthly for the next 12 months. The primary outcomes were the change in best-corrected visual acuity (BCVA) and central retinal thickness (CRT).

At baseline, participants had a mean BCVA of 45.1±11.0 letters, which jumped to 57.8±14.7 letters after 3 months of treatment. The mean gain of 12.7±7.6 letters was statistically significant (p<0.001). By month 12, BCVA further improved to 59.9±12.6 letters (mean age, 14.8±9.5 letters; p<0.001).

On the other hand, CRT dropped significantly with treatment, from 707.0±252.3 µm at baseline to 312.5±t80.3 µm at month 3 and to 278.8±68.8 µm at month 12 (p<0.001 for both). Half of the patients saw a reduction in CRT to normal levels after three injections.

Intravitreal conbercept was also safe overall. There were no reports of severe drug-related ocular or systemic adverse events, though mild side effects were recorded. These included conjunctival haemorrhage, vitreous opacity, and temporary elevations in intraocular pressure.

“Larger case numbers, control groups with blank, or other popular anti-[vascular endothelial growth factor] agents may be used to further confirm the conclusion or indicate the difference between conbercept and other type of anti-VEGFs in the management of CRVO,” the researchers said.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
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