Most Read Articles
24 May 2020
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Roshini Claire Anthony, 2 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

4 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, 3 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.

Intraventricular not superior to oral nimodipine for subarachnoid haemorrhage

14 Mar 2020

In the treatment of patients with aneurysmal subarachnoid haemorrhage, administering the nimodipine via the intraventricular route does not provide greater benefits as compared with the oral route, a recent study has shown.

Researchers recruited patients with World Federation of Neurological Surgeons grades 2–4, modified Fisher grades 2–4, and had an external ventricular drain inserted as part of standard of care. Of the patients, 144 received EG-1962, a sustained release formulation of nimodipine administered via external ventricular drain, and 145 standard of care oral nimodipine.

The study was discontinued prematurely following a planned interim analysis of 210 patients, being unlikely to achieve its primary endpoint of the proportion of patients with favourable outcome at day 90, measured using the extended Glasgow outcome scale 6–8. The proportion was 45 percent (n=65) in the EG-1962 group and 42 percent (n=62) in the oral group (risk ratio, 1.01, 95 percent confidence interval [CI], 0.83–1.22; p=0.95).

However, EG-1962 produced a significant reduction in the number of patients with vasospasm (50 percent vs 63 percent; p=0.025) and hypotension (7 percent vs 10 percent).

Further analysis revealed that EG-1962 was somehow effective in the subgroup of patients with World Federation of Neurological Surgeons 3–4 (46 percent vs 32 percent with oral nimodipine; odds ratio, 1.22, 95 percent CI, 0.94–1.58; p=0.13).

The safety profile of EG-1962 was acceptable.

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Most Read Articles
24 May 2020
The use of capsule endoscopy (CE) appears to be effective in the diagnosis of iron deficiency anaemia (IDA), yielding a 33.9-percent yield in this study, with 65.8 percent of patients undergoing further workup and 12.7 percent requiring therapeutic intervention.
Roshini Claire Anthony, 2 days ago

For coffee drinkers, drinking filtered coffee may be tied to a lower mortality risk, including cardiovascular disease (CVD)-related mortality, a study from Norway suggested.

4 days ago
Eating behaviours have been shown to moderate the relationship between cumulated risk factors in the first 1,000 days and adiposity outcomes at 6 years of age, which underscores modifiable behavioural targets for interventions, reports a study.
Stephen Padilla, 3 days ago
Use of noninvasive ventilation (NIV), similar to invasive mechanical ventilation (IMV), appears to lessen mortality but may increase the risk for transmission of the novel coronavirus disease (COVID-19) in healthcare workers, suggest the results of a study.