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08 Jul 2017
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Intrauterine exposure to oral contraceptives marginally affects pubertal timing

08 Sep 2019

Children exposed to oral contraceptives (OCs) early in pregnancy tend to start puberty and achieve some pubertal milestones at an earlier age, although the magnitude of effect is small and imprecise, a study has found.

The analysis included 15,800 children born during 2000–2003 into the Danish National Birth Cohort, grouped according to maternal use of combined OC pills or progestin-only pills reported around gestational week 17: no exposure (reference; n=11,828), exposure 4 months before conception (n=3,518) and exposure in early pregnancy (n=454). Children self-assessed pubertal status by completing web-based questionnaires from 11 years and biannually throughout puberty.

Intrauterine exposure to OCs showed a tendency toward slightly earlier mean age of achieving some individual pubertal milestones and overall pubertal timing. Specific milestones included voice break (months, −3.8; 95 percent CI, −6.5 to −1.0) and first ejaculation (months, −2.9, −5.9 to 0.1) in boys, and menarche (months, −1.9, −4.0 to 0.3) and Tanner breast stages in girls. The mean age difference for overall pubertal timing was −1.4 months (−3.3 to 0.4) in boys and −0.9 months (−2.7 to 1.0) in girls.

OC exposure prior to conception was not associated with pubertal timing. Furthermore, prepubertal body mass index did not exhibit a mediating effect.

Additional studies are needed, particularly those that that can distinguish between formulations of OCs and timing of exposure in foetal life, owing to the study limitations and rarity of the exposure, researchers said.

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Most Read Articles
08 Jul 2017
Entecavir and lamivudine demonstrate comparable effects on the mortality rate of patients with chronic hepatitis B virus (HBV)-related acute exacerbation with or without acute-on-chronic liver failure (ACLF), reports a study. In patients with ACLF, however, entecavir delivers a more favourable long-term outcome and is associated with greater clinical improvements.
Pearl Toh, 26 Sep 2019
The Singapore Health Sciences Authority (HSA) has recalled eight brands of ranitidine products containing trace amounts of the nitrosamine impurity NDMA*, which is a potential human carcinogen.
05 Oct 2019
The combination of sofosbuvir and velpatasvir is safe and effective for the treatment of hepatitis C virus (HCV) in patients with end-stage renal disease (ESRD) undergoing haemodialysis, a study has shown.
Rachel Soon, 24 Apr 2019

With recent recalls of losartan-containing products contaminated by potentially carcinogenic nitrosamines, MIMS speaks to the Malaysian National Pharmaceutical Regulatory Agency (NPRA) for more details.