Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.

Intranasal desmopressin cuts renal biopsy-related bleeding complications

20 Oct 2019

Administering intranasal desmopressin to patients with renal dysfunction not requiring haemodialysis reduces bleeding complications during renal biopsies, especially minor complications such as perinephric haematomas, a study has found. However, it may increase the risk of incident hyponatraemia.

The study involved 194 nondialysis patients with serum creatinine >132.6 μmol/L and undergoing ultrasound-assisted needle-guided renal biopsy. Of these patients, 105 received 150 μg of desmopressin (D-amino D-arginine vasopressin (DDAVP)) while 89 did not.

Overall and minor bleeding complications occurred less frequently in the treated vs untreated group (15.7 percent vs 31.4 percent and 14 percent vs 27 percent, respectively), as did perinephric haematomas (7.8 percent vs 19 percent; p-all<0.05).

In multivariate logistic regression models, nonuse of desmopressin and female sex emerged as significant predictors of overall risk of bleeding.

However, serum sodium levels dropped in 94 percent of patients treated with desmopressin. Factors associated with greater decrease in serum sodium after treatment were higher estimated glomerular function rate and higher spot urine sodium values.

Researchers explained that a combination of diuretics or renin–angiotensin system (RAS) inhibitors and desmopressin should precipitate hyponatraemia in light of the drugs’ combined effects of salt wasting and water conservation. However, there was no evidence of any positive association between the use of these drugs and the development of hyponatraemia in the study.

The lack of evidence could be attributed to gating or breaking effects due to the continued use of diuretics or intrinsic tubular resistance due to the effects of these drugs, the researchers pointed out. “Nevertheless, as the dose and duration of diuretics and RAS inhibitors were not standardized for all the patients, a role for these drugs in the subsequent development of hyponatraemia cannot be denied based on this study.”

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Most Read Articles
18 May 2020
Immobilization or disuse of the forearm leads to impairment in the ability of a protein-rich meal to promote positive muscle amino acid balance, which is aggravated by dietary lipid oversupply, suggests a study. Disuse also lowers postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.
18 May 2020
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are more effective than basal insulin in the management of total (TC) and low-density lipoprotein cholesterol (LDL-C), reveals a recent study.
17 May 2020
Increased coffee consumption among regular drinkers is associated with higher estimated glomerular filtration rate and confers protection against the risk of chronic kidney disease stages G3–G5 and albuminuria, as shown in a study.
Jairia Dela Cruz, 16 May 2020
Excess weight, greater abdominal fat, inflammation and low physical performance can all contribute to insulin resistance in middle-age Singaporean women, and these variables explain why the condition is more common among women of Chinese than Malay and Indian ethnicities, a study has found.