Most Read Articles
02 Dec 2017
The risk of congenital heart disease (CHD) Is significantly higher in foetuses conceived through in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), according to a recent study.
Pearl Toh, 6 days ago
A higher dose of pitavastatin can benefit Japanese patients with stable coronary artery disease (CAD) compared with a low-dose pitavastatin, even though cardiovascular (CV) event incidence is known to be lower in Asian than Western patients, according to the REAL-CAD study presented at the AHA Scientific Sessions 2017.
01 Apr 2014
The basic life support (BLS) termination of resuscitation (TOR) rule recommends transport and continued resuscitation when cardiac arrest is witnessed by EMT-Ds, or there is a return of spontaneous circulation, or a shock is given.
03 Dec 2017
Treatment with the triple combination of amlodipine, losartan and rosuvastatin appears to be an effective therapeutic strategy for lowering blood pressure and low-density lipoprotein (LDL)-C levels in patients with comorbid hypertension and dyslipidaemia, according to a study.

Intraindividual variability of reaction time predicts all-cause mortality in elderly

22 Aug 2017
Having a greater number of nurses in gerontological nursing will help to better meet the needs of elderly patients.

Higher intraindividual variability of reaction time (IIVRT) predicts all-cause mortality independent of lower global cognition and prodromal dementia, a new study has found.

Over an 8-year follow-up period, the mortality rate in the cohort of 861 elderly adults was 22.2 percent (n=191). The mean survival time was 4.3±2.2 years.

Mean reaction time and median IIVRT were significantly lower in those who died (778.69±238.77 ms and 6.70, respectively) than in survivors (743.19±184.16 ms and 5.85, respectively; p<0.001 and p=0.001, respectively).

Moreover, general cognitive ability (-0.98±1.49 vs -0.43±1.20; p<0.001) was significantly lower in those who died, while cardiovascular disease (CVD) risk score (17.82±3.47 vs 16.97±3.37; p=0.003) was significantly higher.

While both IIVRT (hazard ratio [HR], 1.35; 95 percent CI, 1.15 to 1.59; p<0.001) and mean reaction time (HR, 1.36; 1.20 to 1.54; p<0.001) were significantly associated with all-cause mortality in unadjusted Cox models, only IIVRT remained a significantly predictor of all-cause mortality after adjusting for covariates in multivariate Cox regression models (HR, 1.22; 1.01 to 1.48; p=0.04).

Backward elimination from the fully adjusted model to obtain the best set of all-cause mortality predictors yielded a final model that showed IIVRT (HR, 1.22; 1.00 to 1.47; p=0.045), sex (HR, 1.78; 1.32 to 2.42; p<0.001) and age (HR, 1.13; 1.10 to 1.17; p<0.001) as the best set of predictors.

Notably, cognition scores were not significant predictors of all-cause mortality (HR, 0.88; 0.77 to 1.01; p=0.06).

Participants were recruited from the Sydney Memory and Ageing Study. Those with Mini-Mental State Scores ≤24, with baseline dementia or other neurological conditions and malignancy were excluded.

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Most Read Articles
02 Dec 2017
The risk of congenital heart disease (CHD) Is significantly higher in foetuses conceived through in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI), according to a recent study.
Pearl Toh, 6 days ago
A higher dose of pitavastatin can benefit Japanese patients with stable coronary artery disease (CAD) compared with a low-dose pitavastatin, even though cardiovascular (CV) event incidence is known to be lower in Asian than Western patients, according to the REAL-CAD study presented at the AHA Scientific Sessions 2017.
01 Apr 2014
The basic life support (BLS) termination of resuscitation (TOR) rule recommends transport and continued resuscitation when cardiac arrest is witnessed by EMT-Ds, or there is a return of spontaneous circulation, or a shock is given.
03 Dec 2017
Treatment with the triple combination of amlodipine, losartan and rosuvastatin appears to be an effective therapeutic strategy for lowering blood pressure and low-density lipoprotein (LDL)-C levels in patients with comorbid hypertension and dyslipidaemia, according to a study.