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Jairia Dela Cruz, 05 Oct 2020
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Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

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Intestinal ultrasound useful for evaluating disease, therapeutic response in UC

09 Feb 2020

Intestinal ultrasound is useful in monitoring disease course and evaluating short-term treatment response in patients with ulcerative colitis (UC) and may serve as a viable point-of-care tool in general practice, according to data from the TRUST&UC* study.

TRUST&UC enrolled 253 consecutive patients with a diagnosis of a proctosigmoiditis, left-sided colitis or pancolitis currently in clinical relapse (defined as Short Clinical Colitis Activity Index [SCCAI] ≥5).

A total of 224 patients (88.5 percent) had an increased bowel wall thickness (BWT) in the descending or sigmoid colon at baseline, as assessed using duplex/Colour Doppler ultrasonography. Of these, half had a left-sided colitis while the other half had a pancolitis.

The number of patients with an increased BWT in the sigmoid or descending colon decreased significantly within the first 2 weeks of the study, from 89.3 percent to 38.6 percent and from 83.0 percent to 42.9 percent (p-both<0.001), respectively. This remained low at weeks 6 and 12 (sigmoid colon: 35.4 percent and 32.0 percent; descending colon: 43.4 percent and 37.6 percent; p<0.001).

BWT normalization and clinical response following 12 weeks of treatment were strongly correlated, such that 90.5 percent of patients with normalized BWT had symptomatic response (p<0.001).

The present data provide evidence that monitoring BWT alone has the potential to predict the therapeutic response, which should be verified in future studies, according to researchers.

*The study TRansabdominal Ultrasonography of the bowel in Subjects with IBD To monitor disease activity with UC

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Most Read Articles
Jairia Dela Cruz, 05 Oct 2020
Drinking more than two cups of coffee per day may just be the intervention that prevents hundreds of thousands of liver disease‐related deaths globally, a study reports.
Pearl Toh, 21 Sep 2020
Early and sustained treatments with simplified regimen are the key to achieving good asthma control, said experts during a presentation at the ERS 2020 Congress.
Roshini Claire Anthony, 12 Oct 2020

Insulin icodec, an in-development basal insulin analogue administered once weekly, was as effective as once-daily insulin glargine in patients with type 2 diabetes (T2D) insufficiently controlled with metformin with or without a DPP-4* inhibitor, according to a phase II trial presented at EASD 2020.

Stephen Padilla, 2 days ago
Use of systemic corticosteroids does not reduce in-hospital mortality for patients with severe or critical coronavirus disease (COVID-19), which is in stark contrast to that observed in the RECOVERY clinical trial, according to a study in Wuhan, China.