Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Yesterday
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
5 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
4 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.

Integrate genetic testing into local routine oncology care

Dr Joslyn Ngu
04 Dec 2017

Identification of BRCA mutation in ovarian cancer is vital because it allows better risk management and there is evidence that carriers may benefit from new treatment modalities, said Professor Woo Yin Ling, consultant gynaecological oncologist at the University of Malaya.

Locally, 12 percent of ovarian cancer patients are carriers of a germline BRCA1 or BRCA2 mutations. Genetic counselling plays a crucial role in cancer genetics; interpretation of the results of genetic testing is unique to every individual and her situation, she explained. Unfortunately, there are several barriers to overcome, such as lack of population-based data on genetic mutation in Asians, lack of access to BRCA testing, lack of awareness among healthcare professionals, complex interpretation of genetic test results and psychosocial barriers.

Together with Cancer Research Malaysia, Woo and other healthcare professionals are conducting the MaGiC (MAinstreaming GenetIc Counselling for genetic testing of BRCA1 and BRCA2 in ovarian cancer patients in Malaysia) trial as part of an effort to make genetic counselling mainstream in the country. The study aims to establish a local population-based cohort of ovarian cancer patients to determine the prevalence of mutations, feasibility of mainstreaming BRCA1 and BRCA2 testing for ovarian cancer and psychosocial impact of genetic testing.

Preliminary findings showed the identification of 20 new BRCA carriers from different states in Malaysia. Previously, identified BRCA carriers were mostly from Klang Valley. With the identification of carriers outside of Klang Valley, risk management protocols were then set up in those hospitals and training is provided for clinicians to form multidisciplinary teams for risk management, said Woo. Another preliminary finding is that majority of patients felt counselling done by their doctors were valuable; indicating the importance of physician-led genetic counselling.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Doctor - Malaysia digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
05 Nov 2019
Low total cholesterol levels appear to carry increased major adverse cardiovascular events (MACE) hazard in older men without ischaemic heart disease (IHD) and not receiving statin therapy but not to those on statins, according to data from the CHAMP (Concord Health and Ageing in Men Project) cohort.
Yesterday
Better sleep appears to weaken pain and fatigue in older, community-dwelling adults with hip or knee osteoarthritis (OA), reports a recent study.
5 days ago
Maribavir 400 mg twice daily appears to have comparable efficacy to valganciclovir at clearing cytomegalovirus viraemia in transplant recipients, a study has found.
4 days ago
Individuals with and without gout appear to have a similar risk of developing colorectal cancer, suggesting that gout does not contribute to a risk increase, a study has found.