Most Read Articles
Dr. Joseph Delano Fule Robles, 4 days ago

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

11 Nov 2017
Sensitivity to blue-enriched light is influenced by sex differences, such that males display a stronger response even to very low light levels, a recent study suggests. Moreover, sex differences also affect the acute benefits of bedtime blue light exposure such as sustained attention.
5 days ago
High levels of marijuana exposure appear to not be longitudinally associated with prevalent albuminuria and substantial changes in estimated glomerular filtration rate by cystatin C (eGFRcys), a recent US epidemiological study has shown.
3 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.

Insulin use, diabetic retinopathy predict oesophageal motor disorder in diabetic patients

3 days ago

Close to 50 percent of diabetic patients with dysphagia are found to have some type of an oesophageal motility disorder, according to a new study. Moreover, diabetic retinopathy and insulin use among diabetic patients are risk factors for oesophageal motor abnormalities.

Researchers sought to identify the oesophageal motor characteristics of diabetic vs nondiabetic patients with dysphagia in this study, which included high-resolution oesophageal manometries (HREMs) of 83 diabetic patients and 83 age- and gender-matched nondiabetic patients with dysphagia from two medical centres.

For each patient in a single registry, demographic information, medical comorbidities and medication usage were recorded. In addition, HREM of each patient was assessed and the different functional parameters were recorded.

Forty-six percent of patients with diabetes had an oesophageal motor disorder. Failed swallows on HREM were more likely to occur among diabetic patients with dysphagia than nondiabetic patients (50.6 vs 33.7 percent; p=0.03).

Diabetic patients being treated with insulin were more likely to have failed (69.0 vs 40.7 percent; p=0.01) and weak (65.5 vs 33.3 percent; p=0.005) swallows as compared with those not on insulin. Moreover, diabetic patients with abnormal manometry were more likely to have diabetic retinopathy (27.0 vs 8.7 percent; p=0.04).

Incidence of oesophagogastric junction outflow obstruction was also elevated in diabetic vs nondiabetic patients (10.8 vs 2.4 percent; p=0.057).

In a 2011 study, Basseri and colleagues found that applesauce improves detection of oesophageal motor dysfunction during HREM evaluation of dysphagia and may be preferred to alternative bolus materials. [Dig Dis Sci 2011;56:1723-8]

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Most Read Articles
Dr. Joseph Delano Fule Robles, 4 days ago

A recent study conducted by The University of Hong Kong (HKU) revealed that long-term use of proton pump inhibitors (PPIs) is associated with a significantly increased risk of gastric cancer even in patients who have had Helicobacter pylori eradicated. 

11 Nov 2017
Sensitivity to blue-enriched light is influenced by sex differences, such that males display a stronger response even to very low light levels, a recent study suggests. Moreover, sex differences also affect the acute benefits of bedtime blue light exposure such as sustained attention.
5 days ago
High levels of marijuana exposure appear to not be longitudinally associated with prevalent albuminuria and substantial changes in estimated glomerular filtration rate by cystatin C (eGFRcys), a recent US epidemiological study has shown.
3 days ago
Men with breast cancer have tumours that are typically of the human epidermal growth factor receptor 2-negative Luminal B subtype and positive for oestrogen receptor, progesterone receptor and androgen receptor, according to the results of the EORTC 10085/TBCRC/BIG/NABCG International Male Breast Cancer Program study.