Insulin-like growth factor may help detect liver fibrosis in type 2 diabetics
Among type 2 diabetes mellitus patients without clear alcohol consumption behaviours, there is an inverse correlation between insulin-like growth factor (IGF)-1 and markers of liver fibrosis, a recent study has found.
The study included 415 type 2 diabetes mellitus patients (mean age, 61.9±12.6 years; 248 males) without obvious alcohol intake, from whom 12-hour fasting blood samples were collected. Commercially available assays were used to measure the levels of IGF-1, while criteria from the Japanese Diabetes Society was used to guide diagnosis.
Multiple linear regression analysis revealed an inverse and significant association between IGF-1 levels and the fibrosis-4 index (B, –0.007; 95 percent CI, –0.009 to –0.005; p<0.0001). This association persisted even after adjusting for independent confounders such as body mass index, triglycerides and statin use (B, –0.006; –0.009 to –0.004; p<0.0001).
Similarly, IGF-1 showed an inverse and significant relationship with the 7S domain of type IV collagen (IV-7S; B, –0.009; –0.01 to –0.006; p<0.0001), which likewise persisted after further adjustments for independent and confounding variables (B, –0.007; –0.01 to –0.003; p=0.0004).
Other clinical variables associated with the fibrosis-4 index included body mass index, fasting plasma glucose, glycated haemoglobin and gamma glutamyl transpeptidase. On the other hand, age, platelets, and serum alanine aminotransferase and aspartate aminotransferase levels were some of the factors correlated with IV-7S.
The present findings “might help clinicians to identify type 2 diabetes mellitus patients with advanced [nonalcoholic steatohepatitis] by measuring serum IGF-1 levels. Therefore, we might need to pay attention to IGF-1 in type 2 diabetes mellitus patients,” said researchers.