Most Read Articles
09 May 2019
Nurses who utilize the pen device take less time preparing and administering insulin compared with those who use the vial and syringe method, reports a recent study.
6 days ago
Excessive gains in overall and central fat prior to the childbearing period pose an increased risk of developing gestational diabetes mellitus, a study has found.
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Severe vitamin D deficiency may be detrimental to diabetic patients, with the condition increasing the risk of diabetic foot ulcer, according to the results of a meta-analysis.
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New drug applications approved by US FDA as of 01 - 15 May 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.

Insulin-like growth factor may help detect liver fibrosis in type 2 diabetics

11 Apr 2019

Among type 2 diabetes mellitus patients without clear alcohol consumption behaviours, there is an inverse correlation between insulin-like growth factor (IGF)-1 and markers of liver fibrosis, a recent study has found.

The study included 415 type 2 diabetes mellitus patients (mean age, 61.9±12.6 years; 248 males) without obvious alcohol intake, from whom 12-hour fasting blood samples were collected. Commercially available assays were used to measure the levels of IGF-1, while criteria from the Japanese Diabetes Society was used to guide diagnosis.

Multiple linear regression analysis revealed an inverse and significant association between IGF-1 levels and the fibrosis-4 index (B, –0.007; 95 percent CI, –0.009 to –0.005; p<0.0001). This association persisted even after adjusting for independent confounders such as body mass index, triglycerides and statin use (B, –0.006; –0.009 to –0.004; p<0.0001).

Similarly, IGF-1 showed an inverse and significant relationship with the 7S domain of type IV collagen (IV-7S; B, –0.009; –0.01 to –0.006; p<0.0001), which likewise persisted after further adjustments for independent and confounding variables (B, –0.007; –0.01 to –0.003; p=0.0004).

Other clinical variables associated with the fibrosis-4 index included body mass index, fasting plasma glucose, glycated haemoglobin and gamma glutamyl transpeptidase. On the other hand, age, platelets, and serum alanine aminotransferase and aspartate aminotransferase levels were some of the factors correlated with IV-7S.

The present findings “might help clinicians to identify type 2 diabetes mellitus patients with advanced [nonalcoholic steatohepatitis] by measuring serum IGF-1 levels. Therefore, we might need to pay attention to IGF-1 in type 2 diabetes mellitus patients,” said researchers.

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Most Read Articles
09 May 2019
Nurses who utilize the pen device take less time preparing and administering insulin compared with those who use the vial and syringe method, reports a recent study.
6 days ago
Excessive gains in overall and central fat prior to the childbearing period pose an increased risk of developing gestational diabetes mellitus, a study has found.
24 Apr 2019
Severe vitamin D deficiency may be detrimental to diabetic patients, with the condition increasing the risk of diabetic foot ulcer, according to the results of a meta-analysis.
5 days ago
New drug applications approved by US FDA as of 01 - 15 May 2019 which includes New Molecular Entities (NMEs) and new biologics. It does not include Tentative Approvals. Supplemental approvals may have occurred since the original approval date.