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Insulin-like growth factor-1 inversely correlated with liver fibrosis in diabetics

07 Jan 2019

In type 2 diabetes mellitus (T2DM) patients without obvious alcohol consumption, levels of insulin-like growth factor-I (IGF-I) are inversely associated with liver fibrosis markers, a new study has found.

Using fasting blood samples collected from 415 T2DM patients (mean age 61.9±12.6 years; 248 males), researchers measured levels of IGF-I, as well as of other biomarkers such as fasting plasma glucose, glycated haemoglobin, and low- and high-density lipoprotein cholesterol.

Multiple linear regression analysis showed that IGF-I (B, –0.006; 95 percent CI, –0.009 to –0.004; p<0.0001) and its standard deviation (B, –0.17; –0.25 to –0.10; p<0.0001) were both significantly inversely associated with liver fibrosis, as measured by the fibrosis-4 (FIB-4) index.

A similar trend was observed between the 7S domain of type IV collagen (IV–7S), another measure of liver fibrosis, and IGF-I (B, –0.007; –0.01 to –0.003; p=0.0004) and its standard deviation (B, –0.23; –0.34 to –0.13; p<0.0001).

A subsequent longitudinal observational analysis divided patients into high and low IGF-I groups, using 96.0 ng/mL as the cutoff value. Researchers found that among those with low IGF-I, FIB-4 index scores over 3 years significantly worsened than among those in the high IGF-I group (p=0.049).

“[O]ur findings showed that low serum IGF-I levels are a possible risk factor for liver fibrosis in T2DM patients. This result might help clinicians to identify T2DM patients with advanced [nonalcoholic steatohepatitis] by measuring serum IGF-I levels. Therefore, we might need to pay attention to IGF-I in T2DM patients,” said researchers.

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Most Read Articles
Rachel Soon, 3 days ago

Gels utilizing Stichopus horrens (golden sea cucumber/gamat) extract show a similar efficacy to standard-of-care hydrogels for promoting wound healing, according to a prospective study.

16 Mar 2019
Sleep difficulties are exacerbated in long-term survivors of childhood cancers, which may lead to persistent emotional distress, a new study has found.
2 days ago
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Jairia Dela Cruz, 5 days ago
Use of mirabegron in the treatment of men with overactive bladder (OAB) appears to effectively alleviate urgency and storage symptoms, but not reduce the frequency of micturition episodes, according to data from the MIRACLE study.