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Roshini Claire Anthony, 06 Oct 2020

Several strategies have been proposed to help manage the adverse events (AEs) that emerged during the BEACON CRC trial which assessed the effect of encorafenib plus cetuximab in patients with BRAF V600E mutant metastatic colorectal cancer (mCRC) who had progressed after one or two prior regimens.

Pearl Toh, 15 Nov 2020
Switching to a dual therapy of dolutegravir/lamivudine (DTG/3TC) was noninferior to continuing on a TAF*-based regimen in maintaining virologic suppression over 96 weeks in virally suppressed adults with HIV-1, according to the long-term data from TANGO presented at the 2020 HIV Glasgow Congress.

Insulin beneficial to pregnant women with triglyceride-rich lipoproteins

15 Oct 2020

Women with high levels of very low-density lipoprotein (VLDL) cholesterol or high apolipoprotein B to A-1 ratio (apoB/apoA-1) may fare better with insulin than metformin, with a recent study showing that treatment with the latter leads to higher serum concentrations of triglyceride-rich lipoproteins in the last trimester of pregnancy.

In addition, offspring birth weight tends to increase with higher triglyceride and cholesterol content in VLDL particles.

Researchers conducted a secondary analysis of a randomized trial evaluating the effect of metformin (n=110) vs insulin (n=107) in the treatment of women with gestational diabetes mellitus (GDM) to analyse the associations between individual lipids and offspring birth weight.

Age, prepregnancy body mass index, fasting glucose, HbA1c, and gestational weight gain, among others, were similar in the two treatment groups. Likewise, there were no significant between-group differences seen in absolute mean and adjusted birth weight in children. The incidence of small or large for gestational age was likewise not significantly different.

At 36 gestational weeks, total and VLDL triglycerides and VLDL cholesterol rose from baseline. However, the increase in triglycerides was greater in the metformin-treated group (p<0.01).

Baseline total and VLDL triglycerides, VLDL cholesterol, and apoB/apoA-1 showed a positive association with birth weight, and these relationships were more pronounced in the metformin group.

Among patients in the highest baseline VLDL cholesterol or apoB/apoA-1 quartile, those treated with insulin gave birth to infants with smaller birth weight than those treated with metformin (p<0.03).

Larger studies are needed to confirm the results of the study.

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Most Read Articles
Roshini Claire Anthony, 06 Oct 2020

Several strategies have been proposed to help manage the adverse events (AEs) that emerged during the BEACON CRC trial which assessed the effect of encorafenib plus cetuximab in patients with BRAF V600E mutant metastatic colorectal cancer (mCRC) who had progressed after one or two prior regimens.

Pearl Toh, 15 Nov 2020
Switching to a dual therapy of dolutegravir/lamivudine (DTG/3TC) was noninferior to continuing on a TAF*-based regimen in maintaining virologic suppression over 96 weeks in virally suppressed adults with HIV-1, according to the long-term data from TANGO presented at the 2020 HIV Glasgow Congress.