Most Read Articles
04 Oct 2020
Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.
Roshini Claire Anthony, 3 days ago

Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.

09 Nov 2020
Use of corticosteroids appears to be an effective treatment for paediatric drug reaction with eosinophilia and systemic symptoms (DRESS), suggest the results of a recent study. In severe cases, corticosteroids used in conjunction with intravenous immunoglobulin result in fast clinical improvement.
07 Aug 2020
Concomitant treatment with a nonsteroidal anti-inflammatory drug (NSAID) following myocardial infarction (MI) is associated with a higher risk of cardiovascular and bleeding events, a study has shown.

Insulin beneficial to pregnant women with triglyceride-rich lipoproteins

15 Oct 2020

Women with high levels of very low-density lipoprotein (VLDL) cholesterol or high apolipoprotein B to A-1 ratio (apoB/apoA-1) may fare better with insulin than metformin, with a recent study showing that treatment with the latter leads to higher serum concentrations of triglyceride-rich lipoproteins in the last trimester of pregnancy.

In addition, offspring birth weight tends to increase with higher triglyceride and cholesterol content in VLDL particles.

Researchers conducted a secondary analysis of a randomized trial evaluating the effect of metformin (n=110) vs insulin (n=107) in the treatment of women with gestational diabetes mellitus (GDM) to analyse the associations between individual lipids and offspring birth weight.

Age, prepregnancy body mass index, fasting glucose, HbA1c, and gestational weight gain, among others, were similar in the two treatment groups. Likewise, there were no significant between-group differences seen in absolute mean and adjusted birth weight in children. The incidence of small or large for gestational age was likewise not significantly different.

At 36 gestational weeks, total and VLDL triglycerides and VLDL cholesterol rose from baseline. However, the increase in triglycerides was greater in the metformin-treated group (p<0.01).

Baseline total and VLDL triglycerides, VLDL cholesterol, and apoB/apoA-1 showed a positive association with birth weight, and these relationships were more pronounced in the metformin group.

Among patients in the highest baseline VLDL cholesterol or apoB/apoA-1 quartile, those treated with insulin gave birth to infants with smaller birth weight than those treated with metformin (p<0.03).

Larger studies are needed to confirm the results of the study.

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Most Read Articles
04 Oct 2020
Obesity does not appear to be strongly correlated with an increased risk for febrile neutropaenia during levofloxacin prophylaxis in patients with haematological malignancies receiving intermediate-risk myelosuppressive chemotherapy, suggests a study.
Roshini Claire Anthony, 3 days ago

Initiation or switch to the single-tablet regimen of bictegravir/emtricitabine/tenofovir alafenamide (TAF) led to low HIV-1 RNA viral load in people living with HIV (PLHIV), according to the BICSTaR study presented at HIV Glasgow 2020.

09 Nov 2020
Use of corticosteroids appears to be an effective treatment for paediatric drug reaction with eosinophilia and systemic symptoms (DRESS), suggest the results of a recent study. In severe cases, corticosteroids used in conjunction with intravenous immunoglobulin result in fast clinical improvement.
07 Aug 2020
Concomitant treatment with a nonsteroidal anti-inflammatory drug (NSAID) following myocardial infarction (MI) is associated with a higher risk of cardiovascular and bleeding events, a study has shown.