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Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
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Injectable risperidone effective against acutely exacerbated schizophrenia

12 Jan 2021

Use of long-acting injectable risperidone appears to produce rapid and progressive reduction in symptoms of schizophrenia patients with acute exacerbation, eliminating the need for oral risperidone supplementation or loading doses, according to a study.

In total, 390 patients (mean age, 42 years; 67 percent male; mean body mass index, 28.33 kg/m2) were randomized to receive once-monthly intramuscular injections of long-acting risperidone (75 mg or 100 mg) or placebo for 12 weeks. Treatment was administered every 4 weeks, on days 1, 29, and 57.

The mean Positive and Negative Syndrome Scale (PANSS) score at baseline was 96.4 in the 75-mg group, 96.3 in the 100-mg group, and 96.1 in the placebo group. At day 85, active treatment yielded a significant improvement in the PANSS total score, with placebo-adjusted differences of −13.0 (95 percent confidence interval [CI], −17.3 to −8.8; p<0.0001) with the 75-mg dose and −13.3 (95 percent CI, −17.6 to −8.9; p<0.0001) with the 100-mg dose.

Risperidone was also associated with marked improvements in Clinical Global Impressions-Severity of Illness scale (CGI-S) score compared with placebo (p<0.0001 for both doses).

The improvements in the efficacy outcomes were seen as early as 8 days after the first injection.

Both doses were well tolerated. The most common treatment-emergent adverse events were increased blood prolactin (7.8 percent), headache (7.3 percent), hyperprolactinemia (5 percent), and weight gain (4.8 percent). There were no reports of new or unexpected safety signals.

The findings suggest that injectable risperidone can be an effective therapeutic strategy for schizophrenia patients suffering from an acute episode with severe or moderate psychotic symptoms.

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Most Read Articles
01 Dec 2020
Tetanus toxoid 5 Lf, diphtheria toxoid 2 Lf, pertussis toxoid 2.5 mcg, filamentous haemagglutinin 5 mcg, fimbriae types 2 and 3 5 mcg, pertactin 3 mcg
Dr. Hsu Li Yang, Dr. Tan Thuan Tong, Dr. Andrea Kwa, 08 Jan 2021
Antimicrobial resistance has become increasingly dire as the rapid emergence of drug resistance, especially gram-negative pathogens, has outpaced the development of new antibiotics. At a recent virtual symposium, Dr Hsu Li Yang, Vice Dean (Global Health) and Programme Leader (Infectious Diseases), NUS Saw Swee Hock School of Public Health, presented epidemiological data on multidrug-resistant (MDR) gram-negative bacteria (GNB) in Asia, while Dr Tan Thuan Tong, Head and Senior Consultant, Department of Infectious Diseases, Singapore General Hospital (SGH), focused on the role of ceftazidime-avibactam in MDR GNB infections. Dr Andrea Kwa, Assistant Director of Research, Department of Pharmacy, SGH, joined the panel in an interactive fireside chat, to discuss challenges, practical considerations, and solutions in MDR gram-negative infections. This Pfizer-sponsored symposium was chaired by Dr Ng Shin Yi, Head and Senior Consultant of Surgical Intensive Care, SGH.
Tristan Manalac, Yesterday
While antibody titres against SARS-CoV-2 wane with time, the immune system is capable of producing memory B-cells that can last for at least 6 months after infection, suggesting that the body will be able to protect itself in the case of re-exposure, according to a new study.
Jairia Dela Cruz, 5 days ago
Spending too much time sitting cannot be good for the body, and rising to one's feet breaks up such a behaviour and yields small, but meaningful, reductions in certain cardiovascular disease (CVD) risk factors, according to the results of a meta-analysis.