Most Read Articles
21 Nov 2020
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
6 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

3 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.

Inhaled corticosteroid use carries increased tracheobronchomalacia risk

26 Jan 2020

The use of inhaled corticosteroids (ICS) in the treatment of asthma or chronic obstructive pulmonary disorder (COPD) is associated with an increased risk of tracheobronchomalacia (TBM), according to a study.

Researchers examined the medical records of 153 patients with COPD and 310 with asthma. In the entire cohort, those with vs without TBM were older (68 vs 60 years; p<0.0001), more frequently presented with reflux disease (50 percent vs 16 percent; p<0.0001) and underwent tracheostomy (3.4 percent vs 0.6 percent; p=0.04), and more likely to be on long-acting muscarinic antagonist (LAMA; 50 percent vs 20 percent; p<0.0001) or long-acting beta agonist (LABA; 82 percent vs 55 percent; p<0.0001).

Furthermore, a significantly greater percentage of patients with TBM were on high-dose steroids (56 percent vs 35 percent; p<0.0001). Multivariate logistic regression analysis revealed that the odds of having TBM were three times as great for patients on high-dose vs low-dose ICS (odds ratio, 2.9, 95 percent confidence interval, 1.2–7.1; p=0.02).

Other factors associated with TBM were age (p=0.003), GERD comorbidity (p=0.002), LAMA use (p=0.004), type of ICS (p=0.04) and number of months on ICS (p<0.0001).

The researchers underscored a need for prospective randomized controlled trials to establish causality of the observed association between ICS and TBM.

Digital Edition
Asia's trusted medical magazine for healthcare professionals. Get your MIMS Rheumatology digital copy today!
Sign In To Download
Editor's Recommendations
Most Read Articles
21 Nov 2020
Ivermectin confers benefits in the treatment of COVID-19, with a recent study showing that its use helps reduce the risk of death especially in patients with severe pulmonary involvement.
6 days ago
Mental health comorbidities are common among patients with type 2 diabetes mellitus and may lead to worse outcomes, a recent study has found.
Roshini Claire Anthony, 13 Nov 2020

Diabetes is a key risk factor for heart failure (HF), which is the leading cause of hospitalization in patients with or without diabetes. SGLT-2* inhibitors (SGLT-2is) have been shown to reduce the risk of hospitalization for HF (HHF) regardless of the presence or absence of diabetes.

3 days ago
Vitamin D deficiency may be a contributing factor to the mortality rate among patients with the novel coronavirus disease (COVID-19), reports a new study.