Most Read Articles
01 Apr 2020
Being overweight or obese in adolescence appears to increase the risk of papillary thyroid cancer in adulthood, a recent study has shown.
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
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Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).

Inhaled corticosteroid use carries increased tracheobronchomalacia risk

26 Jan 2020

The use of inhaled corticosteroids (ICS) in the treatment of asthma or chronic obstructive pulmonary disorder (COPD) is associated with an increased risk of tracheobronchomalacia (TBM), according to a study.

Researchers examined the medical records of 153 patients with COPD and 310 with asthma. In the entire cohort, those with vs without TBM were older (68 vs 60 years; p<0.0001), more frequently presented with reflux disease (50 percent vs 16 percent; p<0.0001) and underwent tracheostomy (3.4 percent vs 0.6 percent; p=0.04), and more likely to be on long-acting muscarinic antagonist (LAMA; 50 percent vs 20 percent; p<0.0001) or long-acting beta agonist (LABA; 82 percent vs 55 percent; p<0.0001).

Furthermore, a significantly greater percentage of patients with TBM were on high-dose steroids (56 percent vs 35 percent; p<0.0001). Multivariate logistic regression analysis revealed that the odds of having TBM were three times as great for patients on high-dose vs low-dose ICS (odds ratio, 2.9, 95 percent confidence interval, 1.2–7.1; p=0.02).

Other factors associated with TBM were age (p=0.003), GERD comorbidity (p=0.002), LAMA use (p=0.004), type of ICS (p=0.04) and number of months on ICS (p<0.0001).

The researchers underscored a need for prospective randomized controlled trials to establish causality of the observed association between ICS and TBM.

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Most Read Articles
01 Apr 2020
Being overweight or obese in adolescence appears to increase the risk of papillary thyroid cancer in adulthood, a recent study has shown.
3 days ago
A recent study reports a mean growth rate of proximal aorta of about 0.1 mm/year in hypertensive patients with known aortic dilatation. In addition, those with increased rather than normal aortic z score have slower dilatation over time.
Tristan Manalac, 2 days ago
The coronavirus disease 2019 (COVID-19) appears to be more dangerous among cancer patients, who tend suffer more severe complications and faster disease progression, according to a new study.
01 Apr 2020
Knee osteoarthritis (OA), whether symptomatic or radiographic, contributes to an increased risk of all-cause mortality, with the risk increase from symptomatic knee OA partially attributed to its effect on disability and quality of life (QoL).