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Pearl Toh, 6 days ago
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11 Jan 2020
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Stephen Padilla, 4 days ago
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Roshini Claire Anthony, 3 days ago

Regular tea consumption may be linked to reduced incidence and mortality from atherosclerotic cardiovascular disease (ASCVD), according to a study from China.

Inhalable mRNA dry powder promising for lung disease management

Christina Lau
21 Nov 2019

An inhalable dry powder formulation of mRNA developed by researchers at the University of Hong Kong has shown promise in the treatment of lung diseases.

The formulation was developed using PEG12KL4, a pegylated cationic peptide, as RNA delivery vector. With the use of spray drying and spray freeze drying techniques, PEG12KL4/mRNA complexes were formulated into dry powder with satisfactory aerosol properties for inhalation. [J Control Release 2019;314:102-115]

Intratracheal administration of luciferase mRNA using the above formulation resulted in luciferase expression in the deep lung region of mice 24 hours post-transfection, with superior transfection efficiency compared with naked mRNA or lipoplexes, which led to weaker luciferase expression in the tracheal region only. No sign of inflammatory response or toxicity was reported with the PEG12KL4/mRNA complexes following a single intratracheal administration.

According to the investigators, the inhalable mRNA dry powder can potentially be used to treat lung diseases such as asthma, chronic obstructive pulmonary disease and cancer. The team is now developing an inhalable mRNA vaccine based on their discovery.

The inhalable mRNA dry powder is more stable and patient-friendly, with a lower treatment cost, compared with liquid formulations administered by nebulization using bulky devices, they added.

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Most Read Articles
Pearl Toh, 6 days ago
Obeticholic acid significantly improves fibrosis and disease activity in patients with nonalcoholic steatohepatitis (NASH), a chronic liver disease currently with no approved therapy, according to an interim analysis of the landmark REGENERATE* study.
11 Jan 2020
Prevention of glucocorticoid-induced osteoporosis (GIOP) and postmenopausal osteoporosis (PMOP) remains inadequate in patients with rheumatoid arthritis (RA), as shown in a study that evaluated the implementation of the 2003 and 2014 French guidelines on the prevention and treatment of GIOP and the 2012 update of the French guidelines for the treatment of PMOP.
Stephen Padilla, 4 days ago
Patients with nonalcoholic fatty liver disease (NAFLD) tend to consume more energy, macronutrients, added sugar and fructose than the controls, as shown in a Singapore study. Waist circumference and energy consumption, but not fructose intake, significantly correlate with NAFLD.
Roshini Claire Anthony, 3 days ago

Regular tea consumption may be linked to reduced incidence and mortality from atherosclerotic cardiovascular disease (ASCVD), according to a study from China.